| Reaction Details |
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 | Report a problem with these data |
| Target | Collagenase 3 |
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| Ligand | BDBM50095569 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_106477 (CHEMBL719146) |
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| IC50 | 0.8±n/a nM |
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| Citation |  Natchus, MG; Bookland, RG; De, B; Almstead, NG; Pikul, S; Janusz, MJ; Heitmeyer, SA; Hookfin, EB; Hsieh, LC; Dowty, ME; Dietsch, CR; Patel, VS; Garver, SM; Gu, F; Pokross, ME; Mieling, GE; Baker, TR; Foltz, DJ; Peng, SX; Bornes, DM; Strojnowski, MJ; Taiwo, YO Development of new hydroxamate matrix metalloproteinase inhibitors derived from functionalized 4-aminoprolines. J Med Chem43:4948-63 (2001) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Collagenase 3 |
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| Name: | Collagenase 3 |
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| Synonyms: | MMP-13 | MMP13 | MMP13_HUMAN | Matrix metalloproteinase-13 | Matrix metalloproteinase-13 (MMP-13) | Matrix metalloproteinase-13 (MMP13) |
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| Type: | Enzyme |
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| Mol. Mass.: | 53808.06 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P45452 |
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| Residue: | 471 |
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| Sequence: | MHPGVLAAFLFLSWTHCRALPLPSGGDEDDLSEEDLQFAERYLRSYYHPTNLAGILKENA
ASSMTERLREMQSFFGLEVTGKLDDNTLDVMKKPRCGVPDVGEYNVFPRTLKWSKMNLTY
RIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDG
PSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALM
FPIYTYTGKSHFMLPDDDVQGIQSLYGPGDEDPNPKHPKTPDKCDPSLSLDAITSLRGET
MIFKDRFFWRLHPQQVDAELFLTKSFWPELPNRIDAAYEHPSHDLIFIFRGRKFWALNGY
DILEGYPKKISELGLPKEVKKISAAVHFEDTGKTLLFSGNQVWRYDDTNHIMDKDYPRLI
EEDFPGIGDKVDAVYEKNGYIYFFNGPIQFEYSIWSNRIVRVMPANSILWC
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| BDBM50095569 |
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| n/a |
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| Name | BDBM50095569 |
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| Synonyms: | 4-(Methanesulfonyl-propyl-amino)-1-(4-methoxy-benzenesulfonyl)-pyrrolidine-2-carboxylic acid hydroxyamide | CHEMBL147629 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H25N3O7S2 |
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| Mol. Mass. | 435.516 |
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| SMILES | CCCN([C@H]1C[C@@H](N(C1)S(=O)(=O)c1ccc(OC)cc1)C(=O)NO)S(C)(=O)=O |
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| Structure | 
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