| Reaction Details |
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 | Report a problem with these data |
| Target | Stromelysin-1 |
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| Ligand | BDBM50095538 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_104571 (CHEMBL714854) |
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| IC50 | 2±n/a nM |
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| Citation |  Natchus, MG; Bookland, RG; De, B; Almstead, NG; Pikul, S; Janusz, MJ; Heitmeyer, SA; Hookfin, EB; Hsieh, LC; Dowty, ME; Dietsch, CR; Patel, VS; Garver, SM; Gu, F; Pokross, ME; Mieling, GE; Baker, TR; Foltz, DJ; Peng, SX; Bornes, DM; Strojnowski, MJ; Taiwo, YO Development of new hydroxamate matrix metalloproteinase inhibitors derived from functionalized 4-aminoprolines. J Med Chem43:4948-63 (2001) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Stromelysin-1 |
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| Name: | Stromelysin-1 |
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| Synonyms: | MMP-3 | MMP3 | MMP3_HUMAN | Matrix metalloproteinase (2 and 3) | Matrix metalloproteinase 3 | Matrix metalloproteinase-3 | Matrix metalloproteinase-3 (MMP-3) | Matrix metalloproteinase-3 (MMP3) | SL-1 | STMY1 | Stromelysin 1 | Transin-1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 53973.13 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P08254 |
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| Residue: | 477 |
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| Sequence: | MKSLPILLLLCVAVCSAYPLDGAARGEDTSMNLVQKYLENYYDLKKDVKQFVRRKDSGPV
VKKIREMQKFLGLEVTGKLDSDTLEVMRKPRCGVPDVGHFRTFPGIPKWRKTHLTYRIVN
YTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNV
LAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLY
HSLTDLTRFRLSQDDINGIQSLYGPPPDSPETPLVPTEPVPPEPGTPANCDPALSFDAVS
TLRGEILIFKDRHFWRKSLRKLEPELHLISSFWPSLPSGVDAAYEVTSKDLVFIFKGNQF
WAIRGNEVRAGYPRGIHTLGFPPTVRKIDAAISDKEKNKTYFFVEDKYWRFDEKRNSMEP
GFPKQIAEDFPGIDSKIDAVFEEFGFFYFFTGSSQLEFDPNAKKVTHTLKSNSWLNC
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| BDBM50095538 |
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| n/a |
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| Name | BDBM50095538 |
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| Synonyms: | 1-(4-Butoxy-benzenesulfonyl)-4-(3-methyl-2,5-dioxo-imidazolidin-1-yl)-pyrrolidine-2-carboxylic acid hydroxyamide | CHEMBL342102 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H26N4O7S |
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| Mol. Mass. | 454.497 |
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| SMILES | CCCCOc1ccc(cc1)S(=O)(=O)N1C[C@H](C[C@@H]1C(=O)NO)n1c(O)cn(C)c1=O |
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| Structure | 
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