Ki Summary

Reaction Details

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Target

Serine/threonine-protein kinase DCLK1

Ligand

BDBM50337135

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_1979827 (CHEMBL4612962)

IC50

187±n/a nM

Citation

Ferguson, FM; Liu, Y; Harshbarger, W; Huang, L; Wang, J; Deng, X; Capuzzi, SJ; Muratov, EN; Tropsha, A; Muthuswamy, S; Westover, KD; Gray, NS Synthesis and Structure-Activity Relationships of DCLK1 Kinase Inhibitors Based on a 5,11-Dihydro-6 J Med Chem63:7817-7826 (2020) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Serine/threonine-protein kinase DCLK1

Name:

Serine/threonine-protein kinase DCLK1

Synonyms:

Type:

PROTEIN

Mol. Mass.:

82239.64

Organism:

Homo sapiens (Human)

Description:

ChEMBL_774446

Residue:

740

Sequence:

MSFGRDMELEHFDERDKAQRYSRGSRVNGLPSPTHSAHCSFYRTRTLQTLSSEKKAKKVR
FYRNGDRYFKGIVYAISPDRFRSFEALLADLTRTLSDNVNLPQGVRTIYTIDGLKKISSL
DQLVEGESYVCGSIEPFKKLEYTKNVNPNWSVNVKTTSASRAVSSLATAKGSPSEVRENK
DFIRPKLVTIIRSGVKPRKAVRILLNKKTAHSFEQVLTDITDAIKLDSGVVKRLYTLDGK
QVMCLQDFFGDDDIFIACGPEKFRYQDDFLLDESECRVVKSTSYTKIASSSRRSTTKSPG
PSRRSKSPASTSSVNGTPGSQLSTPRSGKSPSPSPTSPGSLRKQRSSQHGGSSTSLASTK
VCSSMDENDGPGEEVSEEGFQIPATITERYKVGRTIGDGNFAVVKECVERSTAREYALKI
IKKSKCRGKEHMIQNEVSILRRVKHPNIVLLIEEMDVPTELYLVMELVKGGDLFDAITST
NKYTERDASGMLYNLASAIKYLHSLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIV
DGPLYTVCGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPFRGSGDDQEVLFDQ
ILMGQVDFPSPYWDNVSDSAKELITMMLLVDVDQRFSAVQVLEHPWVNDDGLPENEHQLS
VAGKIKKHFNTGPKPNSTAAGVSVIATTALDKERQVFRRRRNQDVRSRYKAQPAPPELNS
ESEDYSPSSSETVRSPNSPF

BDBM50337135

n/a

Name

BDBM50337135

Synonyms:

4-((5,11-dimethyl-6-oxo-6,11-dihydro-5H-benzo[e]pyrimido[5,4-b][1,4]diazepin-2-yl)amino)benzenesulfonamide | Benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one, 6 | CHEMBL1673047 | US11155556, No. 16

Type

Small organic molecule

Emp. Form.

C19H18N6O3S

Mol. Mass.

410.45

SMILES

CN1c2ccccc2C(=O)N(C)c2cnc(Nc3ccc(cc3)S(N)(=O)=O)nc12

Structure