| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase DCLK1 |
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| Ligand | BDBM50539952 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1979827 (CHEMBL4612962) |
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| IC50 | 214±n/a nM |
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| Citation |  Ferguson, FM; Liu, Y; Harshbarger, W; Huang, L; Wang, J; Deng, X; Capuzzi, SJ; Muratov, EN; Tropsha, A; Muthuswamy, S; Westover, KD; Gray, NS Synthesis and Structure-Activity Relationships of DCLK1 Kinase Inhibitors Based on a 5,11-Dihydro-6 J Med Chem63:7817-7826 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase DCLK1 |
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| Name: | Serine/threonine-protein kinase DCLK1 |
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| Synonyms: | DCAMKL1 | DCDC3A | DCLK1 | DCLK1_HUMAN | KIAA0369 | Serine/threonine-protein kinase DCLK1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 82239.64 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_774446 |
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| Residue: | 740 |
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| Sequence: | MSFGRDMELEHFDERDKAQRYSRGSRVNGLPSPTHSAHCSFYRTRTLQTLSSEKKAKKVR
FYRNGDRYFKGIVYAISPDRFRSFEALLADLTRTLSDNVNLPQGVRTIYTIDGLKKISSL
DQLVEGESYVCGSIEPFKKLEYTKNVNPNWSVNVKTTSASRAVSSLATAKGSPSEVRENK
DFIRPKLVTIIRSGVKPRKAVRILLNKKTAHSFEQVLTDITDAIKLDSGVVKRLYTLDGK
QVMCLQDFFGDDDIFIACGPEKFRYQDDFLLDESECRVVKSTSYTKIASSSRRSTTKSPG
PSRRSKSPASTSSVNGTPGSQLSTPRSGKSPSPSPTSPGSLRKQRSSQHGGSSTSLASTK
VCSSMDENDGPGEEVSEEGFQIPATITERYKVGRTIGDGNFAVVKECVERSTAREYALKI
IKKSKCRGKEHMIQNEVSILRRVKHPNIVLLIEEMDVPTELYLVMELVKGGDLFDAITST
NKYTERDASGMLYNLASAIKYLHSLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIV
DGPLYTVCGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPFRGSGDDQEVLFDQ
ILMGQVDFPSPYWDNVSDSAKELITMMLLVDVDQRFSAVQVLEHPWVNDDGLPENEHQLS
VAGKIKKHFNTGPKPNSTAAGVSVIATTALDKERQVFRRRRNQDVRSRYKAQPAPPELNS
ESEDYSPSSSETVRSPNSPF
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| BDBM50539952 |
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| n/a |
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| Name | BDBM50539952 |
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| Synonyms: | CHEMBL4645722 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H32F3N7O2 |
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| Mol. Mass. | 555.5946 |
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| SMILES | CC(C)Oc1cc(ccc1Nc1ncc2N(CC(F)(F)F)C(=O)c3ccccc3N(C)c2n1)N1CCN(C)CC1 |
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| Structure | 
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