| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Mas-related G-protein coupled receptor member X2 |
|---|
| Ligand | BDBM391726 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1979867 (CHEMBL4613002) |
|---|
| EC50 | 900±n/a nM |
|---|
| Citation |  Bucknell, SJ; Ator, MA; Brown, AJH; Brown, J; Cansfield, AD; Cansfield, JE; Christopher, JA; Congreve, M; Cseke, G; Deflorian, F; Jones, CR; Mason, JS; O'Brien, MA; Ott, GR; Pickworth, M; Southall, SM Structure-Based Drug Discovery of J Med Chem63:7906-7920 (2020) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Mas-related G-protein coupled receptor member X2 |
|---|
| Name: | Mas-related G-protein coupled receptor member X2 |
|---|
| Synonyms: | MRGPRX2 | MRGX2 | MRGX2_HUMAN | Mas-related G protein-coupled receptor X2 (MRGPRX2) | Mas-related G-protein coupled receptor member X2 |
|---|
| Type: | GPCR |
|---|
| Mol. Mass.: | 37104.79 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q96LB1 |
|---|
| Residue: | 330 |
|---|
| Sequence: | MDPTTPAWGTESTTVNGNDQALLLLCGKETLIPVFLILFIALVGLVGNGFVLWLLGFRMR
RNAFSVYVLSLAGADFLFLCFQIINCLVYLSNFFCSISINFPSFFTTVMTCAYLAGLSML
STVSTERCLSVLWPIWYRCRRPRHLSAVVCVLLWALSLLLSILEGKFCGFLFSDGDSGWC
QTFDFITAAWLIFLFMVLCGSSLALLVRILCGSRGLPLTRLYLTILLTVLVFLLCGLPFG
IQWFLILWIWKDSDVLFCHIHPVSVVLSSLNSSANPIIYFFVGSFRKQWRLQQPILKLAL
QRALQDIAEVDHSEGCFRQGTPEMSRSSLV
|
|
|
|---|
| BDBM391726 |
|---|
| n/a |
|---|
| Name | BDBM391726 |
|---|
| Synonyms: | N-[(2R)-3-(7-methyl-1H- | US10300056, Example 11 | US10888561, Example 11 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C40H49N11O5 |
|---|
| Mol. Mass. | 763.8878 |
|---|
| SMILES | Cc1cc(C[C@@H](NC(=O)N2CCC3(CC2)OC(=O)Nc2ncccc32)C(=O)N[C@@H](CC2CCNCC2)C(=O)N2CCN(CC2)c2ccncc2)cc2cn[nH]c12 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
