Reaction Details |
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Target | Polycomb protein EED |
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Ligand | BDBM225230 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1979924 (CHEMBL4613059) |
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IC50 | 18±n/a nM |
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Citation | Rej, RK; Wang, C; Lu, J; Wang, M; Petrunak, E; Zawacki, KP; McEachern, D; Fernandez-Salas, E; Yang, CY; Wang, L; Li, R; Chinnaswamy, K; Wen, B; Sun, D; Stuckey, J; Zhou, Y; Chen, J; Tang, G; Wang, S EEDi-5285: An Exceptionally Potent, Efficacious, and Orally Active Small-Molecule Inhibitor of Embryonic Ectoderm Development. J Med Chem63:7252-7267 (2020) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Polycomb protein EED |
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Name: | Polycomb protein EED |
Synonyms: | EED | EED_HUMAN | WAIT-1 | WD protein associating with integrin cytoplasmic tails 1 | hEED |
Type: | Protein |
Mol. Mass.: | 50201.68 |
Organism: | Homo sapiens (Human) |
Description: | O75530 |
Residue: | 441 |
Sequence: | MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTP
NAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNR
VTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITM
QCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVL
SADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFS
TRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQ
CDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSR
DSSILIAVCDDASIWRWDRLR
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BDBM225230 |
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n/a |
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Name | BDBM225230 |
Synonyms: | EED226 | US11013745, Compound EED226 |
Type | Small organic molecule |
Emp. Form. | C17H15N5O3S |
Mol. Mass. | 369.398 |
SMILES | CS(=O)(=O)c1ccc(cc1)-c1cnc(NCc2ccco2)n2cnnc12 |
Structure |
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