| Reaction Details |
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 | Report a problem with these data |
| Target | Casein kinase II subunit alpha'/beta |
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| Ligand | BDBM50530315 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1979999 (CHEMBL4613134) |
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| Ki | 86±n/a nM |
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| Citation |  Lindenblatt, D; Nickelsen, A; Applegate, VM; Jose, J; Niefind, K Structural and Mechanistic Basis of the Inhibitory Potency of Selected 2-Aminothiazole Compounds on Protein Kinase CK2. J Med Chem63:7766-7772 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Casein kinase II subunit alpha'/beta |
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| Name: | Casein kinase II subunit alpha'/beta |
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| Synonyms: | Casein kinase II alpha''''/ beta | Casein kinase II alpha''/ beta | Casein kinase II alpha'/ beta |
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| Type: | n/a |
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| Mol. Mass.: | n/a |
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| Description: | ASSAY_ID of ChEMBL is 794696 |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Casein kinase II subunit beta |
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| Synonyms: | CK2N | CSK2B_HUMAN | CSNK2B | Casein kinase II subunit beta | Casein kinase II subunit beta (CK2 beta) | Casein kinase II subunit beta (CK2β) | G5A | Serine/threonine-protein kinase pim-2 |
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| Type: | Enzyme |
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| Mol. Mass.: | 24937.13 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P67870 |
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| Residue: | 215 |
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| Sequence: | MSSSEEVSWISWFCGLRGNEFFCEVDEDYIQDKFNLTGLNEQVPHYRQALDMILDLEPDE
ELEDNPNQSDLIEQAAEMLYGLIHARYILTNRGIAQMLEKYQQGDFGYCPRVYCENQPML
PIGLSDIPGEAMVKLYCPKCMDVYTPKSSRHHHTDGAYFGTGFPHMLFMVHPEYRPKRPA
NQFVPRLYGFKIHPMAYQLQLQAASNFKSPVKTIR
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| Component 2 |
| Name: | Casein kinase II subunit alpha' |
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| Synonyms: | CK2A2 | CSK22_HUMAN | CSNK2A2 | Casein kinase II alpha (prime) | Casein kinase II alpha' | Casein kinase II subunit alpha (CK2A2) | Casein kinase II subunit alpha (CSNK2A2) |
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| Type: | Protein |
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| Mol. Mass.: | 41223.82 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 350 |
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| Sequence: | MPGPAAGSRARVYAEVNSLRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINI
TNNERVVVKILKPVKKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNT
DFKQLYQILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLA
EFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNY
DQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALD
LLDKLLRYDHQQRLTAKEAMEHPYFYPVVKEQSQPCADNAVLSSGLTAAR
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| BDBM50530315 |
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| n/a |
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| Name | BDBM50530315 |
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| Synonyms: | CHEMBL4520531 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H14N2O3S |
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| Mol. Mass. | 362.402 |
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| SMILES | OC(=O)c1ccc(Nc2nc(cs2)-c2ccc3ccccc3c2)cc1O |
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| Structure | 
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