| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Endoplasmin |
|---|
| Ligand | BDBM50540251 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1981019 (CHEMBL4614281) |
|---|
| IC50 | 192±n/a nM |
|---|
| Citation |  Jung, S; Yoon, NG; Yang, S; Kim, D; Lee, WS; Hong, KB; Lee, C; Kang, BH; Lee, JH; Kang, S Discovery of 2-((4-resorcinolyl)-5-aryl-1,2,3-triazol-1-yl)acetates as potent Hsp90 inhibitors with selectivity over TRAP1. Bioorg Med Chem Lett30:0 (2020) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Endoplasmin |
|---|
| Name: | Endoplasmin |
|---|
| Synonyms: | 94 kDa glucose-regulated protein | ENPL_HUMAN | GRP-94 | GRP94 | Glucose regulated protein 94kDa (Grp94) | HSP90B1 | Heat shock protein 90 kDa beta member 1 | TRA1 | Tumor rejection antigen 1 | gp96 homolog |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 92417.36 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P14625 |
|---|
| Residue: | 803 |
|---|
| Sequence: | MRALWVLGLCCVLLTFGSVRADDEVDVDGTVEEDLGKSREGSRTDDEVVQREEEAIQLDG
LNASQIRELREKSEKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISL
TDENALSGNEELTVKIKCDKEKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTE
AQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSNEFSVIADPRGNT
LGRGTTITLVLKEEASDYLELDTIKNLVKKYSQFINFPIYVWSSKTETVEEPMEEEEAAK
EEKEESDDEAAVEEEEEEKKPKTKKVEKTVWDWELMNDIKPIWQRPSKEVEEDEYKAFYK
SFSKESDDPMAYIHFTAEGEVTFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITD
DFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKVIRKKLVRKTLDMIKKIADDKY
NDTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHHPTDITSLDQYVERMKEKQDKIYF
MAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDE
SEKTKESREAVEKEFEPLLNWMKDKALKDKIEKAVVSQRLTESPCALVASQYGWSGNMER
IMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRIKEDEDDKTVLDLAVVLFET
ATLRSGYLLPDTKAYGDRIERMLRLSLNIDPDAKVEEEPEEEPEETAEDTTEDTEQDEDE
EMDVGTDEEEETAKESTAEKDEL
|
|
|
|---|
| BDBM50540251 |
|---|
| n/a |
|---|
| Name | BDBM50540251 |
|---|
| Synonyms: | CHEMBL4641450 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H25N3O6 |
|---|
| Mol. Mass. | 439.4611 |
|---|
| SMILES | CCOC(=O)Cn1nnc(c1-c1ccc2OCCOc2c1)-c1cc(C(C)C)c(O)cc1O |
|---|
| Structure | 
|
|---|
Search and Browse
