| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cathepsin K |
|---|
| Ligand | BDBM50096392 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_216707 |
|---|
| Ki | 10.00±n/a nM |
|---|
| Citation |  Fenwick, AE; Gribble, AD; Ife, RJ; Stevens, N; Witherington, J Diastereoselective synthesis, activity and chiral stability of cyclic alkoxyketone inhibitors of cathepsin K. Bioorg Med Chem Lett11:199-202 (2001) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cathepsin K |
|---|
| Name: | Cathepsin K |
|---|
| Synonyms: | CATK_HUMAN | CTSK | CTSO | CTSO2 | Cathepsin O | Cathepsin O2 | Cathepsin X |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 36975.68 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P43235 |
|---|
| Residue: | 329 |
|---|
| Sequence: | MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIH
NLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVD
YRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGG
YMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVA
RVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGE
NWGNKGYILMARNKNNACGIANLASFPKM
|
|
|
|---|
| BDBM50096392 |
|---|
| n/a |
|---|
| Name | BDBM50096392 |
|---|
| Synonyms: | (S)-2-[2-(3,4-Dimethoxy-phenyl)-acetylamino]-4-methyl-pentanoic acid (3-oxo-tetrahydro-pyran-4-yl)-amide | CHEMBL61820 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H30N2O6 |
|---|
| Mol. Mass. | 406.4727 |
|---|
| SMILES | COc1ccc(CC(=O)N[C@@H](CC(C)C)C(=O)NC2CCOCC2=O)cc1OC |
|---|
| Structure | 
|
|---|
Search and Browse
