| Reaction Details |
|---|
 | Report a problem with these data |
| Target | 72 kDa type IV collagenase |
|---|
| Ligand | BDBM50096652 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_104377 |
|---|
| IC50 | 36±n/a nM |
|---|
| Citation |  Chollet, AM; Le Diguarher, T; Murray, L; Bertrand, M; Tucker, GC; Sabatini, M; Pierré, A; Atassi, G; Bonnet, J; Casara, P General synthesis of alpha-substituted 3-bisaryloxy propionic acid derivatives as specific MMP inhibitors. Bioorg Med Chem Lett11:295-9 (2001) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| 72 kDa type IV collagenase |
|---|
| Name: | 72 kDa type IV collagenase |
|---|
| Synonyms: | 72 kDa gelatinase | 72 kDa type IV collagenase precursor | CLG4A | Gelatinase A | Gelatinase A (MMP-2) | MMP2 | MMP2_HUMAN | Matrix metalloproteinase-2 | Matrix metalloproteinase-2 (MMP 2) | Matrix metalloproteinase-2 (MMP2) | Matrix metalloproteinases 2 (MMP-2) | TBE-1 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 73870.36 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P08253 |
|---|
| Residue: | 660 |
|---|
| Sequence: | MEALMARGALTGPLRALCLLGCLLSHAAAAPSPIIKFPGDVAPKTDKELAVQYLNTFYGC
PKESCNLFVLKDTLKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPDVANYNFFPRKPKWD
KNQITYRIIGYTPDLDPETVDDAFARAFQVWSDVTPLRFSRIHDGEADIMINFGRWEHGD
GYPFDGKDGLLAHAFAPGTGVGGDSHFDDDELWTLGEGQVVRVKYGNADGEYCKFPFLFN
GKEYNSCTDTGRSDGFLWCSTTYNFEKDGKYGFCPHEALFTMGGNAEGQPCKFPFRFQGT
SYDSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAPCVFPFTFLGNKY
ESCTSAGRSDGKMWCATTANYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGAL
MAPIYTYTKNFRLSQDDIKGIQELYGASPDIDLGTGPTPTLGPVTPEICKQDIVFDGIAQ
IRGEIFFFKDRFIWRTVTPRDKPMGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEY
WIYSASTLERGYPKPLTSLGLPPDVQRVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDP
GFPKLIADAWNAIPDNLDAVVDLQGGGHSYFFKGAYYLKLENQSLKSVKFGSIKSDWLGC
|
|
|
|---|
| BDBM50096652 |
|---|
| n/a |
|---|
| Name | BDBM50096652 |
|---|
| Synonyms: | 2-(Biphenyl-4-yloxymethyl)-N-hydroxy-4-(3,4,4-trimethyl-2,5-dioxo-imidazolidin-1-yl)-butyramide | CHEMBL323148 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H27N3O5 |
|---|
| Mol. Mass. | 425.4776 |
|---|
| SMILES | CN1C(=O)N(CCC(COc2ccc(cc2)-c2ccccc2)C(=O)NO)C(=O)C1(C)C |
|---|
| Structure | 
|
|---|
Search and Browse
