Reaction Details |
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Target | Glycogen synthase kinase-3 beta |
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Ligand | BDBM50267626 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1982701 (CHEMBL4615963) |
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Ki | 31±n/a nM |
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Citation | Prati, F; Buonfiglio, R; Furlotti, G; Cavarischia, C; Mangano, G; Picollo, R; Oggianu, L; di Matteo, A; Olivieri, S; Bovi, G; Porceddu, PF; Reggiani, A; Garrone, B; Di Giorgio, FP; Ombrato, R Optimization of Indazole-Based GSK-3 Inhibitors with Mitigated hERG Issue and ACS Med Chem Lett11:825-831 (2020) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Glycogen synthase kinase-3 beta |
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Name: | Glycogen synthase kinase-3 beta |
Synonyms: | GSK-3 beta | GSK-3, beta | GSK3B | GSK3B_HUMAN | Glycogen synthase kinase 3 beta (GSK3B) | Glycogen synthase kinase 3-beta (GSK3B) | Glycogen synthase kinase-3 beta (GSK-3B) | Glycogen synthase kinase-3 beta (GSK3 Beta) | Glycogen synthase kinase-3 beta (GSK3B) | Glycogen synthase kinase-3B (GSK-3B) | Glycogen synthase kinase-3beta (GSK3B) | Serine/threonine-protein kinase GSK3B |
Type: | Enzyme |
Mol. Mass.: | 46756.38 |
Organism: | Homo sapiens (Human) |
Description: | P49841 |
Residue: | 420 |
Sequence: | MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTK
VIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSG
EKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHR
DIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDV
WSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHP
WTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALF
NFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST
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BDBM50267626 |
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n/a |
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Name | BDBM50267626 |
Synonyms: | AZ-11548415 | AZD-1080 |
Type | Small organic molecule |
Emp. Form. | C19H18N4O2 |
Mol. Mass. | 334.3718 |
SMILES | Oc1[nH]c2ccc(cc2c1-c1ccc(CN2CCOCC2)cn1)C#N |
Structure |
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