Reaction Details |
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Target | Poly [ADP-ribose] polymerase 2 |
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Ligand | BDBM27497 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1982742 (CHEMBL4616004) |
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IC50 | 15±n/a nM |
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Citation | Tomassi, S; Pfahler, J; Mautone, N; Rovere, A; Esposito, C; Passeri, D; Pellicciari, R; Novellino, E; Pannek, M; Steegborn, C; Paiardini, A; Mai, A; Rotili, D From PARP1 to TNKS2 Inhibition: A Structure-Based Approach. ACS Med Chem Lett11:862-868 (2020) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Poly [ADP-ribose] polymerase 2 |
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Name: | Poly [ADP-ribose] polymerase 2 |
Synonyms: | (ARTD2 or PARP2) | ADPRT2 | ADPRTL2 | PARP2 | PARP2_HUMAN | Poly [ADP-ribose] polymerase 2 (PARP-2) | Poly [ADP-ribose] polymerase 2 (PARP2) |
Type: | Enzyme |
Mol. Mass.: | 66225.70 |
Organism: | Homo sapiens (Human) |
Description: | Q9UGN5 |
Residue: | 583 |
Sequence: | MAARRRRSTGGGRARALNESKRVNNGNTAPEDSSPAKKTRRCQRQESKKMPVAGGKANKD
RTEDKQDGMPGRSWASKRVSESVKALLLKGKAPVDPECTAKVGKAHVYCEGNDVYDVMLN
QTNLQFNNNKYYLIQLLEDDAQRNFSVWMRWGRVGKMGQHSLVACSGNLNKAKEIFQKKF
LDKTKNNWEDREKFEKVPGKYDMLQMDYATNTQDEEETKKEESLKSPLKPESQLDLRVQE
LIKLICNVQAMEEMMMEMKYNTKKAPLGKLTVAQIKAGYQSLKKIEDCIRAGQHGRALME
ACNEFYTRIPHDFGLRTPPLIRTQKELSEKIQLLEALGDIEIAIKLVKTELQSPEHPLDQ
HYRNLHCALRPLDHESYEFKVISQYLQSTHAPTHSDYTMTLLDLFEVEKDGEKEAFREDL
HNRMLLWHGSRMSNWVGILSHGLRIAPPEAPITGYMFGKGIYFADMSSKSANYCFASRLK
NTGLLLLSEVALGQCNELLEANPKAEGLLQGKHSTKGLGKMAPSSAHFVTLNGSTVPLGP
ASDTGILNPDGYTLNYNEYIVYNPNQVRMRYLLKVQFNFLQLW
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BDBM27497 |
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n/a |
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Name | BDBM27497 |
Synonyms: | 2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridin-2-yl)acetamide | 2-Dimethylamino-N-(6-oxo-5,6-dihydro-phenanthridin-2-yl)-acetamide | CHEMBL372303 | N-(6-oxo-5,6-dihydro- phenanthridin-2-yl)-N,N-dimethylacetamide | N~2~,N~2~-DIMETHYL-N~1~-(6-OXO-5,6-DIHYDROPHENANTHRIDIN-2-YL)GLYCINAMIDE | PJ34 |
Type | Small organic molecule |
Emp. Form. | C17H17N3O2 |
Mol. Mass. | 295.3358 |
SMILES | CN(C)CC(=O)Nc1ccc2[nH]c(=O)c3ccccc3c2c1 |
Structure |
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