| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Eukaryotic initiation factor 4A-I |
|---|
| Ligand | BDBM50235738 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1983224 (CHEMBL4616486) |
|---|
| IC50 | 426±n/a nM |
|---|
| Citation |  Ernst, JT; Thompson, PA; Nilewski, C; Sprengeler, PA; Sperry, S; Packard, G; Michels, T; Xiang, A; Tran, C; Wegerski, CJ; Eam, B; Young, NP; Fish, S; Chen, J; Howard, H; Staunton, J; Molter, J; Clarine, J; Nevarez, A; Chiang, GG; Appleman, JR; Webster, KR; Reich, SH Design of Development Candidate eFT226, a First in Class Inhibitor of Eukaryotic Initiation Factor 4A RNA Helicase. J Med Chem63:5879-5955 (2020) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Eukaryotic initiation factor 4A-I |
|---|
| Name: | Eukaryotic initiation factor 4A-I |
|---|
| Synonyms: | ATP-dependent RNA helicase eIF4A-1 | DDX2A | EIF4A | EIF4A1 | IF4A1_HUMAN | eIF-4A-I | eIF4A-I |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 46146.87 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_864983 |
|---|
| Residue: | 406 |
|---|
| Sequence: | MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQ
RAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVV
MALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFV
LDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEE
LTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVS
AMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRI
GRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI
|
|
|
|---|
| BDBM50235738 |
|---|
| n/a |
|---|
| Name | BDBM50235738 |
|---|
| Synonyms: | Hippuristanol |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C28H46O5 |
|---|
| Mol. Mass. | 462.6618 |
|---|
| SMILES | [H][C@]12C[C@@]3([H])[C@]4([H])CC[C@@]5([H])C[C@H](O)CC[C@]5(C)[C@@]4([H])[C@@H](O)C[C@]3(C)[C@@]1([H])[C@@](C)(O)[C@]1(C[C@H](C)C(C)(C)O1)O2 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
