| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Nonstructural protein 5A |
|---|
| Ligand | BDBM50387084 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1984013 (CHEMBL4617419) |
|---|
| EC50 | 0.009000±n/a nM |
|---|
| Citation |  Nakamura, H; Akagi, Y; Terui, T; Fujioka, S; Komoda, Y; Kinoshita, W; Maeda, K; Ukaji, Y; Inaba, T Discovery of a novel unsymmetrical structural class of HCV NS5A inhibitors with low picomolar antiviral activity. Bioorg Med Chem Lett30:0 (2020) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Nonstructural protein 5A |
|---|
| Name: | Nonstructural protein 5A |
|---|
| Synonyms: | NS5A | Nonstructural protein 5A |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 48587.20 |
|---|
| Organism: | Hepatitis C virus |
|---|
| Description: | ChEMBL_108438 |
|---|
| Residue: | 447 |
|---|
| Sequence: | SGSWLRDVWDWICTVLTDFKTWLQSKLLPRIPGVPFLSCQRGYKGVWRGDGIMHTTCPCG
AQITGHVKNGSMRIVGPKTCSNTWHGTFPINTYTTGPCTPSPAPNYSRALWRVAAEEYVE
VTRVGDFHYVTGMTTDNVKCPCQVPAPEFFTEVDGVRLHRYAPACKPLLREEVTFMVGLN
QYLVGSQLPCEPEPDVTVLTSMLTDPSHITAETAGRRLARGSPPSLASSSASQLSAPSLK
ATCTTRHDSPDADLIEANLLWRQEMGGNITRVESENKVVILDSFDPLQAEEDEREVSVPA
EILRKSRKFPRAMPIWARPDYNPPLLESWKDPDYVPPVVHGCPLPPAKAPPIPPPRRKRT
VVLTESTVSSALAELATKTFGSSGSSAVDSGTATAPPDQLPGDGDSGSDVESYSSMPPLE
GEPGDPDLSDGSWSTMSEEASEDVVCC
|
|
|
|---|
| BDBM50387084 |
|---|
| n/a |
|---|
| Name | BDBM50387084 |
|---|
| Synonyms: | BMS-790052 | DACLATASVIR |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C40H50N8O6 |
|---|
| Mol. Mass. | 738.875 |
|---|
| SMILES | COC(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1c1nc(c[nH]1)-c1ccc(cc1)-c1ccc(cc1)-c1c[nH]c(n1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)C(C)C |r| |
|---|
| Structure | 
|
|---|
Search and Browse
