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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase ABL1/ABL2 | ||
| Ligand | BDBM50097944 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_226186 (CHEMBL846552) | ||
| IC50 | 230±n/a nM | ||
| Citation |  Widler, L; Green, J; Missbach, M; Susa, M; Altmann, E 7-Alkyl- and 7-cycloalkyl-5-aryl-pyrrolo[2,3-d]pyrimidines--potent inhibitors of the tyrosine kinase c-Src. Bioorg Med Chem Lett11:849-52 (2001) [PubMed] | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase ABL1/ABL2 | |||
| Name: | Tyrosine-protein kinase ABL1/ABL2 | ||
| Synonyms: | Tyrosine-protein kinase ABL | ||
| Type: | n/a | ||
| Mol. Mass.: | n/a | ||
| Description: | ASSAY_ID of EBI is 226000 | ||
| Components: | This complex has 2 components. | ||
| Component 1 | |||
| Name: | Tyrosine-protein kinase ABL1 | ||
| Synonyms: | ABL | ABL1 | ABL1_HUMAN | Abelson murine leukemia viral oncogene homolog 1 | JTK7 | Proto-oncogene c-Abl | Proto-oncogene tyrosine-protein kinase ABL1 | Tyrosine-protein kinase (ABL) | Tyrosine-protein kinase ABL | Tyrosine-protein kinase ABL1 (ABL) | V-abl Abelson murine leukemia viral oncogene homolog 1 | c-ABL | p150 | tyrosine-protein kinase ABL1 isoform a | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 122897.30 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P00519 | ||
| Residue: | 1130 | ||
| Sequence: |
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| Component 2 | |||
| Name: | Tyrosine-protein kinase ABL2 | ||
| Synonyms: | ABL2 | ABL2_HUMAN | ABLL | ARG | Abelson murine leukemia viral oncogene homolog 2 | Abelson-related gene protein | Tyrosine kinase ARG | VHL/Tyrosine-protein kinase ABL2 | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 128360.63 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_325082 | ||
| Residue: | 1182 | ||
| Sequence: |
| ||
| BDBM50097944 | |||
| n/a | |||
| Name | BDBM50097944 | ||
| Synonyms: | 3-[4-Amino-5-(3-methoxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutanecarboxylic acid (2-hydroxy-ethyl)-amide | CHEMBL354310 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C20H23N5O3 | ||
| Mol. Mass. | 381.4283 | ||
| SMILES | COc1cccc(c1)-c1cn(C2CC(C2)C(=O)NCCO)c2ncnc(N)c12 |(14.27,-.7,;13.8,-2.17,;12.3,-2.49,;11.27,-1.34,;9.75,-1.69,;9.28,-3.16,;10.32,-4.29,;11.83,-3.96,;9.85,-5.75,;10.78,-7,;9.87,-8.25,;10.36,-9.71,;9.66,-11.08,;11.04,-11.77,;11.72,-10.39,;11.29,-13.29,;12.72,-13.85,;10.08,-14.26,;10.32,-15.79,;9.13,-16.75,;9.36,-18.27,;8.39,-7.79,;7.05,-8.57,;5.71,-7.79,;5.71,-6.24,;7.05,-5.47,;7.04,-3.93,;8.39,-6.24,)| | ||
| Structure | 
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