| Reaction Details |
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 | Report a problem with these data |
| Target | 5-hydroxytryptamine receptor 2C |
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| Ligand | BDBM50038370 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2822 (CHEMBL621508) |
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| Ki | 3.78±n/a nM |
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| Citation |  Chambers, JJ; Kurrasch-Orbaugh, DM; Parker, MA; Nichols, DE Enantiospecific synthesis and pharmacological evaluation of a series of super-potent, conformationally restricted 5-HT(2A/2C) receptor agonists. J Med Chem44:1003-10 (2001) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| 5-hydroxytryptamine receptor 2C |
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| Name: | 5-hydroxytryptamine receptor 2C |
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| Synonyms: | 5-HT2C | 5-hydroxytryptamine receptor 2C | 5-hydroxytryptamine receptor 2C (5HT2c) | 5HT2C_RAT | 5ht1c | Htr1c | Htr2c | Serotonin (5-HT) receptor | Serotonin receptor 2a and 2c (5HT2A and 5HT2C) |
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| Type: | Enzyme |
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| Mol. Mass.: | 51935.10 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | P08909 |
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| Residue: | 460 |
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| Sequence: | MVNLGNAVRSLLMHLIGLLVWQFDISISPVAAIVTDTFNSSDGGRLFQFPDGVQNWPALS
IVVIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYV
WPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVW
AISIGVSVPIPVIGLRDESKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYFLTIY
VLRRQTLMLLRGHTEEELANMSLNFLNCCCKKNGGEEENAPNPNPDQKPRRKKKEKRPRG
TMQAINNEKKASKVLGIVFFVFLIMWCPFFITNILSVLCGKACNQKLMEKLLNVFVWIGY
VCSGINPLVYTLFNKIYRRAFSKYLRCDYKPDKKPPVRQIPRVAATALSGRELNVNIYRH
TNERVARKANDPEPGIEMQVENLELPVNPSNVVSERISSV
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|
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| BDBM50038370 |
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| n/a |
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| Name | BDBM50038370 |
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| Synonyms: | 2-(2,5-Dimethoxy-4-trifluoromethyl-phenyl)-1-methyl-ethylamine | CHEMBL6620 | Racemic DOTFM |
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| Type | Small organic molecule |
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| Emp. Form. | C12H16F3NO2 |
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| Mol. Mass. | 263.2561 |
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| SMILES | COc1cc(c(OC)cc1CC(C)N)C(F)(F)F |
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| Structure | 
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