Reaction Details |
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Target | Gag-Pol polyprotein [489-587] |
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Ligand | BDBM50541882 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1985519 (CHEMBL4618925) |
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Ki | 8.5±n/a nM |
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Citation | Zhu, M; Dou, Y; Ma, L; Dong, B; Zhang, F; Zhang, G; Wang, J; Zhou, J; Cen, S; Wang, Y Novel HIV-1 Protease Inhibitors with Morpholine as the P2 Ligand to Enhance Activity against DRV-Resistant Variants. ACS Med Chem Lett11:1196-1204 (2020) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Gag-Pol polyprotein [489-587] |
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Name: | Gag-Pol polyprotein [489-587] |
Synonyms: | Human immunodeficiency virus type 1 protease | POL_HV1H2 | Pol polyprotein | gag-pol |
Type: | Enzyme Subunit |
Mol. Mass.: | 10781.16 |
Organism: | Human immunodeficiency virus type 1 |
Description: | P04585[489-587] |
Residue: | 99 |
Sequence: | PQVTLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYD
QILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
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BDBM50541882 |
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n/a |
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Name | BDBM50541882 |
Synonyms: | CHEMBL4634362 |
Type | Small organic molecule |
Emp. Form. | C26H38N4O5S |
Mol. Mass. | 518.669 |
SMILES | CC(C)CN(C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)CN1CCOCC1)S(=O)(=O)c1ccc(N)cc1 |r| |
Structure |
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