Reaction Details |
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Target | Acidic mammalian chitinase |
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Ligand | BDBM50541941 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1985608 (CHEMBL4619014) |
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IC50 | 49±n/a nM |
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Citation | Andryianau, G; Kowalski, M; Piotrowicz, MC; Rajkiewicz, AA; Dymek, B; Sklepkiewicz, PL; Pluta, E; Stefaniak, F; Czestkowski, W; Olejniczak, S; Mazur, M; Niedziejko, P; Koralewski, R; Matyszewski, K; Gruza, M; Zagozdzon, A; Salamon, M; Rymaszewska, A; Welzer, M; Dzwonek, K; Golab, J; Olczak, J; Bartoszewicz, A; Golebiowski, A Benzoxazepine-Derived Selective, Orally Bioavailable Inhibitor of Human Acidic Mammalian Chitinase. ACS Med Chem Lett11:1228-1235 (2020) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Acidic mammalian chitinase |
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Name: | Acidic mammalian chitinase |
Synonyms: | AMCase | Acidic mammalian chitinase (AMCase) | CHIA | CHIA_HUMAN | Lung-specific protein TSA1902 |
Type: | Protein |
Mol. Mass.: | 52266.66 |
Organism: | Homo sapiens (Human) |
Description: | Q9BZP6 |
Residue: | 476 |
Sequence: | MTKLILLTGLVLILNLQLGSAYQLTCYFTNWAQYRPGLGRFMPDNIDPCLCTHLIYAFAG
RQNNEITTIEWNDVTLYQAFNGLKNKNSQLKTLLAIGGWNFGTAPFTAMVSTPENRQTFI
TSVIKFLRQYEFDGLDFDWEYPGSRGSPPQDKHLFTVLVQEMREAFEQEAKQINKPRLMV
TAAVAAGISNIQSGYEIPQLSQYLDYIHVMTYDLHGSWEGYTGENSPLYKYPTDTGSNAY
LNVDYVMNYWKDNGAPAEKLIVGFPTYGHNFILSNPSNTGIGAPTSGAGPAGPYAKESGI
WAYYEICTFLKNGATQGWDAPQEVPYAYQGNVWVGYDNIKSFDIKAQWLKHNKFGGAMVW
AIDLDDFTGTFCNQGKFPLISTLKKALGLQSASCTAPAQPIEPITAAPSGSGNGSGSSSS
GGSSGGSGFCAVRANGLYPVANNRNAFWHCVNGVTYQQNCQAGLVFDTSCDCCNWA
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BDBM50541941 |
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n/a |
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Name | BDBM50541941 |
Synonyms: | CHEMBL4647895 |
Type | Small organic molecule |
Emp. Form. | C24H26ClN7O |
Mol. Mass. | 463.963 |
SMILES | Nc1nc(n[nH]1)N1CCC(CC1)N1Cc2cc(ccc2OC[C@@H]1Cc1ccc(Cl)cc1)C#N |r| |
Structure |
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