| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Chitotriosidase-1 |
|---|
| Ligand | BDBM50243795 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1985609 (CHEMBL4619015) |
|---|
| IC50 | 104±n/a nM |
|---|
| Citation |  Andryianau, G; Kowalski, M; Piotrowicz, MC; Rajkiewicz, AA; Dymek, B; Sklepkiewicz, PL; Pluta, E; Stefaniak, F; Czestkowski, W; Olejniczak, S; Mazur, M; Niedziejko, P; Koralewski, R; Matyszewski, K; Gruza, M; Zagozdzon, A; Salamon, M; Rymaszewska, A; Welzer, M; Dzwonek, K; Golab, J; Olczak, J; Bartoszewicz, A; Golebiowski, A Benzoxazepine-Derived Selective, Orally Bioavailable Inhibitor of Human Acidic Mammalian Chitinase. ACS Med Chem Lett11:1228-1235 (2020) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Chitotriosidase-1 |
|---|
| Name: | Chitotriosidase-1 |
|---|
| Synonyms: | CHIT1 | CHIT1_HUMAN | Chitinase 1 | Chitinase-1 | Chitotriosidase | Chitotriosidase-1 | Chitotriosidase-1 (CHIT1) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 51682.25 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q13231 |
|---|
| Residue: | 466 |
|---|
| Sequence: | MVRSVAWAGFMVLLMIPWGSAAKLVCYFTNWAQYRQGEARFLPKDLDPSLCTHLIYAFAG
MTNHQLSTTEWNDETLYQEFNGLKKMNPKLKTLLAIGGWNFGTQKFTDMVATANNRQTFV
NSAIRFLRKYSFDGLDLDWEYPGSQGSPAVDKERFTTLVQDLANAFQQEAQTSGKERLLL
SAAVPAGQTYVDAGYEVDKIAQNLDFVNLMAYDFHGSWEKVTGHNSPLYKRQEESGAAAS
LNVDAAVQQWLQKGTPASKLILGMPTYGRSFTLASSSDTRVGAPATGSGTPGPFTKEGGM
LAYYEVCSWKGATKQRIQDQKVPYIFRDNQWVGFDDVESFKTKVSYLKQKGLGGAMVWAL
DLDDFAGFSCNQGRYPLIQTLRQELSLPYLPSGTPELEVPKPGQPSEPEHGPSPGQDTFC
QGKADGLYPNPRERSSFYSCAAGRLFQQSCPTGLVFSNSCKCCTWN
|
|
|
|---|
| BDBM50243795 |
|---|
| n/a |
|---|
| Name | BDBM50243795 |
|---|
| Synonyms: | CHEMBL4077644 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H26Cl2N6 |
|---|
| Mol. Mass. | 445.388 |
|---|
| SMILES | Nc1n[nH]c(n1)N1CCC(CC1)N(CCc1ccc(Cl)cc1)Cc1ccccc1Cl |
|---|
| Structure | 
|
|---|
Search and Browse
