Ki Summary

Reaction Details

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Target

C-C chemokine receptor type 1

Ligand

BDBM50098628

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_218695 (CHEMBL821481)

IC50

270±n/a nM

Citation

Naya, A; Sagara, Y; Ohwaki, K; Saeki, T; Ichikawa, D; Iwasawa, Y; Noguchi, K; Ohtake, N Design, synthesis, and discovery of a novel CCR1 antagonist. J Med Chem44:1429-35 (2001) [PubMed]

More Info.:

Get all data from this article, Assay Method

C-C chemokine receptor type 1

Name:

C-C chemokine receptor type 1

Synonyms:

Type:

PROTEIN

Mol. Mass.:

40904.59

Organism:

Mus musculus

Description:

ChEMBL_1452291

Residue:

355

Sequence:

MEISDFTEAYPTTTEFDYGDSTPCQKTAVRAFGAGLLPPLYSLVFIIGVVGNVLVILVLM
QHRRLQSMTSIYLFNLAVSDLVFLFTLPFWIDYKLKDDWIFGDAMCKLLSGFYYLGLYSE
IFFIILLTIDRYLAIVHAVFALRARTVTFGIITSIITWALAILASMPALYFFKAQWEFTH
RTCSPHFPYKSLKQWKRFQALKLNLLGLILPLLVMIICYAGIIRILLRRPSEKKVKAVRL
IFAITLLFFLLWTPYNLSVFVSAFQDVLFTNQCEQSKQLDLAMQVTEVIAYTHCCVNPII
YVFVGERFWKYLRQLFQRHVAIPLAKWLPFLSVDQLERTSSISPSTGEHELSAGF

BDBM50098628

n/a

Name

BDBM50098628

Synonyms:

1-Cyclooct-1-enylmethyl-1-propyl-4-[(9H-xanthene-9-carbonyl)-amino]-piperidinium; iodide | CHEMBL33050

Type

Small organic molecule

Emp. Form.

C31H41N2O2

Mol. Mass.

473.6689

SMILES

CCC[N+]1(C\C2=C\CCCCCC2)CCC(CC1)NC(=O)C1c2ccccc2Oc2ccccc12 |t:5,(8.83,-27.51,;8.85,-29.05,;7.53,-29.84,;7.54,-31.38,;8.89,-32.15,;10.45,-31.45,;11.87,-32.05,;13.28,-31.45,;13.88,-30.04,;13.28,-28.6,;11.87,-28.02,;10.45,-28.62,;9.85,-30.04,;6.2,-30.62,;4.88,-31.38,;4.78,-33.12,;6.23,-33.69,;7.57,-32.9,;3.44,-33.89,;2.22,-32.9,;2.21,-31.38,;.91,-33.69,;.91,-35.22,;2.22,-36,;2.22,-37.53,;.88,-38.28,;-.45,-37.51,;-.44,-35.99,;-1.78,-35.22,;-1.76,-33.69,;-3.08,-32.93,;-3.1,-31.38,;-1.75,-30.61,;-.42,-31.38,;-.42,-32.9,)|

Structure