Reaction Details |
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Target | Estrogen receptor |
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Ligand | BDBM50090462 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1985949 (CHEMBL4619355) |
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IC50 | 1.7±n/a nM |
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Citation | Liang, J; Blake, R; Chang, J; Friedman, LS; Goodacre, S; Hartman, S; Ingalla, ER; Kiefer, JR; Kleinheinz, T; Labadie, S; Li, J; Lai, KW; Liao, J; Mody, V; McLean, N; Metcalfe, C; Nannini, M; Otwine, D; Ran, Y; Ray, N; Roussel, F; Sambrone, A; Sampath, D; Vinogradova, M; Wai, J; Wang, T; Yeap, K; Young, A; Zbieg, J; Zhang, B; Zheng, X; Zhong, Y; Wang, X Discovery of GNE-149 as a Full Antagonist and Efficient Degrader of Estrogen Receptor alpha for ER+ Breast Cancer. ACS Med Chem Lett11:1342-1347 (2020) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Estrogen receptor |
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Name: | Estrogen receptor |
Synonyms: | ER | ER-alpha | ESR | ESR1 | ESR1_HUMAN | Estradiol receptor | Estrogen receptor | Estrogen receptor (ER alpha) | Estrogen receptor (ER-alpha) | Estrogen receptor alpha (ER alpha) | Estrogen receptor alpha (ER) | NR3A1 | Nuclear receptor subfamily 3 group A member 1 |
Type: | Protein |
Mol. Mass.: | 66230.44 |
Organism: | Homo sapiens (Human) |
Description: | P03372 |
Residue: | 595 |
Sequence: | MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAY
EFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPF
LQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAK
ETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQAC
RLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKR
SKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINW
AKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEG
MVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLD
KITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLL
LEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV
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BDBM50090462 |
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n/a |
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Name | BDBM50090462 |
Synonyms: | CHEMBL3581693 | US20240043442, Example GDC-0810 |
Type | Small organic molecule |
Emp. Form. | C26H20ClFN2O2 |
Mol. Mass. | 446.901 |
SMILES | CC\C(=C(\c1ccc(\C=C\C(O)=O)cc1)c1ccc2[nH]ncc2c1)c1ccc(F)cc1Cl |
Structure |
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