| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Leucine--tRNA ligase |
|---|
| Ligand | BDBM50241779 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1986947 (CHEMBL4620494) |
|---|
| IC50 | 216±n/a nM |
|---|
| Citation |  Makarov, V; Salina, E; Reynolds, RC; Kyaw Zin, PP; Ekins, S Molecule Property Analyses of Active Compounds for J Med Chem63:8917-8955 (2020) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Leucine--tRNA ligase |
|---|
| Name: | Leucine--tRNA ligase |
|---|
| Synonyms: | 6.1.1.4 | LeuRS | Leucine--tRNA ligase | Leucyl-tRNA synthetase | SYL_MYCTU | leuS |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 107566.69 |
|---|
| Organism: | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
|---|
| Description: | ChEMBL_117449 |
|---|
| Residue: | 969 |
|---|
| Sequence: | MTESPTAGPGGVPRADDADSDVPRYRYTAELAARLERTWQENWARLGTFNVPNPVGSLAP
PDGAAVPDDKLFVQDMFPYPSGEGLHVGHPLGYIATDVYARYFRMVGRNVLHALGFDAFG
LPAEQYAVQTGTHPRTRTEANVVNFRRQLGRLGFGHDSRRSFSTTDVDFYRWTQWIFLQI
YNAWFDTTANKARPISELVAEFESGARCLDGGRDWAKLTAGERADVIDEYRLVYRADSLV
NWCPGLGTVLANEEVTADGRSDRGNFPVFRKRLRQWMMRITAYADRLLDDLDVLDWPEQV
KTMQRNWIGRSTGAVALFSARAASDDGFEVDIEVFTTRPDTLFGATYLVLAPEHDLVDEL
VAASWPAGVNPLWTYGGGTPGEAIAAYRRAIAAKSDLERQESREKTGVFLGSYAINPANG
EPVPIFIADYVLAGYGTGAIMAVPGHDQRDWDFARAFGLPIVEVIAGGNISESAYTGDGI
LVNSDYLNGMSVPAAKRAIVDRLESAGRGRARIEFKLRDWLFARQRYWGEPFPIVYDSDG
RPHALDEAALPVELPDVPDYSPVLFDPDDADSEPSPPLAKATEWVHVDLDLGDGLKPYSR
DTNVMPQWAGSSWYELRYTDPHNSERFCAKENEAYWMGPRPAEHGPDDPGGVDLYVGGAE
HAVLHLLYSRFWHKVLYDLGHVSSREPYRRLVNQGYIQAYAYTDARGSYVPAEQVIERGD
RFVYPGPDGEVEVFQEFGKIGKSLKNSVSPDEICDAYGADTLRVYEMSMGPLEASRPWAT
KDVVGAYRFLQRVWRLVVDEHTGETRVADGVELDIDTLRALHRTIVGVSEDFAALRNNTA
TAKLIEYTNHLTKKHRDAVPRAAVEPLVQMLAPLAPHIAEELWLRLGNTTSLAHGPFPKA
DAAYLVDETVEYPVQVNGKVRGRVVVAADTDEETLKAAVLTDEKVQAFLAGATPRKVIVV
AGRLVNLVI
|
|
|
|---|
| BDBM50241779 |
|---|
| n/a |
|---|
| Name | BDBM50241779 |
|---|
| Synonyms: | CHEMBL4082159 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C10H14BCl2NO4 |
|---|
| Mol. Mass. | 293.939 |
|---|
| SMILES | Cl.NC[C@H]1OB(O)c2c1c(Cl)ccc2OCCO |r| |
|---|
| Structure | 
|
|---|
Search and Browse
