| Reaction Details |
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 | Report a problem with these data |
| Target | Dual specificity protein kinase TTK |
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| Ligand | BDBM259464 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1987223 (CHEMBL4620770) |
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| IC50 | 1.3±n/a nM |
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| Citation |  Schulze, VK; Klar, U; Kosemund, D; Wengner, AM; Siemeister, G; Stöckigt, D; Neuhaus, R; Lienau, P; Bader, B; Prechtl, S; Holton, SJ; Briem, H; Marquardt, T; Schirok, H; Jautelat, R; Bohlmann, R; Nguyen, D; Fernández-Montalván, AE; Bömer, U; Eberspaecher, U; Brüning, M; Döhr, O; Raschke, M; Kreft, B; Mumberg, D; Ziegelbauer, K; Brands, M; von Nussbaum, F; Koppitz, M Treating Cancer by Spindle Assembly Checkpoint Abrogation: Discovery of Two Clinical Candidates, BAY 1161909 and BAY 1217389, Targeting MPS1 Kinase. J Med Chem63:8025-8042 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dual specificity protein kinase TTK |
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| Name: | Dual specificity protein kinase TTK |
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| Synonyms: | Dual specificity protein kinase (TTK) | Dual specificity protein kinase TTK (MPS1) | MPS1 | MPS1L1 | Monopolar Spindle 1 (MPS1) | Monopolar Spindle 1 (Mps-1) | Monopolar Spindle 1 Kinase (MPS1) | Phosphotyrosine picked threonine-protein kinase (MPS1) | TTK | TTK_HUMAN |
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| Type: | Protein |
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| Mol. Mass.: | 97086.79 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P33981 |
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| Residue: | 857 |
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| Sequence: | MESEDLSGRELTIDSIMNKVRDIKNKFKNEDLTDELSLNKISADTTDNSGTVNQIMMMAN
NPEDWLSLLLKLEKNSVPLSDALLNKLIGRYSQAIEALPPDKYGQNESFARIQVRFAELK
AIQEPDDARDYFQMARANCKKFAFVHISFAQFELSQGNVKKSKQLLQKAVERGAVPLEML
EIALRNLNLQKKQLLSEEEKKNLSASTVLTAQESFSGSLGHLQNRNNSCDSRGQTTKARF
LYGENMPPQDAEIGYRNSLRQTNKTKQSCPFGRVPVNLLNSPDCDVKTDDSVVPCFMKRQ
TSRSECRDLVVPGSKPSGNDSCELRNLKSVQNSHFKEPLVSDEKSSELIITDSITLKNKT
ESSLLAKLEETKEYQEPEVPESNQKQWQSKRKSECINQNPAASSNHWQIPELARKVNTEQ
KHTTFEQPVFSVSKQSPPISTSKWFDPKSICKTPSSNTLDDYMSCFRTPVVKNDFPPACQ
LSTPYGQPACFQQQQHQILATPLQNLQVLASSSANECISVKGRIYSILKQIGSGGSSKVF
QVLNEKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSDKIIRLYDYEITDQYIYM
VMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLIVDGML
KLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSL
GCILYYMTYGKTPFQQIINQISKLHAIIDPNHEIEFPDIPEKDLQDVLKCCLKRDPKQRI
SIPELLAHPYVQIQTHPVNQMAKGTTEEMKYVLGQLVGLNSPNSILKAAKTLYEHYSGGE
SHNSSSSKTFEKKRGKK
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| BDBM259464 |
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| n/a |
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| Name | BDBM259464 |
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| Synonyms: | US9512126, 1 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H27F4N5O2 |
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| Mol. Mass. | 553.5506 |
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| SMILES | COc1ccc(cc1F)C(=C)c1cc(NCCC(F)(F)F)c2ncc(-c3ccc(C(=O)NC4CC4)c(C)c3)n2n1 |
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| Structure | 
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