| Reaction Details |
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 | Report a problem with these data |
| Target | N-terminal Xaa-Pro-Lys N-methyltransferase 1 |
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| Ligand | BDBM50542788 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1988001 (CHEMBL4621548) |
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| Ki | 6.8±n/a nM |
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| Citation |  Chen, D; Dong, C; Dong, G; Srinivasan, K; Min, J; Noinaj, N; Huang, R Probing the Plasticity in the Active Site of Protein N-terminal Methyltransferase 1 Using Bisubstrate Analogues. J Med Chem63:8419-8431 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| N-terminal Xaa-Pro-Lys N-methyltransferase 1 |
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| Name: | N-terminal Xaa-Pro-Lys N-methyltransferase 1 |
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| Synonyms: | 2.1.1.244 | Alpha N-terminal protein methyltransferase 1A | C9orf32 | METTL11A | Methyltransferase-like protein 11A | N-terminal RCC1 methyltransferase | N-terminal Xaa-Pro-Lys N-methyltransferase 1 | N-terminal Xaa-Pro-Lys N-methyltransferase 1, N-terminally processed | NRMT | NRMT1 | NRMT1 | NTM1A | NTM1A_HUMAN | NTMT1 | X-Pro-Lys N-terminal protein methyltransferase 1A |
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| Type: | PROTEIN |
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| Mol. Mass.: | 25382.72 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_119192 |
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| Residue: | 223 |
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| Sequence: | MTSEVIEDEKQFYSKAKTYWKQIPPTVDGMLGGYGHISSIDINSSRKFLQRFLREGPNKT
GTSCALDCGAGIGRITKRLLLPLFREVDMVDITEDFLVQAKTYLGEEGKRVRNYFCCGLQ
DFTPEPDSYDVIWIQWVIGHLTDQHLAEFLRRCKGSLRPNGIIVIKDNMAQEGVILDDVD
SSVCRDLDVVRRIICSAGLSLLAEERQENLPDEIYHVYSFALR
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| BDBM50542788 |
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| n/a |
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| Name | BDBM50542788 |
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| Synonyms: | CHEMBL4645959 |
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| Type | Small organic molecule |
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| Emp. Form. | C44H76N18O11 |
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| Mol. Mass. | 1033.1882 |
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| SMILES | CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNCCN(CC[C@H](N)C(O)=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)C(=O)N[C@@H](C)C(N)=O |r| |
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| Structure | 
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