Reaction Details |
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Target | Sigma non-opioid intracellular receptor 1 |
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Ligand | BDBM50099818 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_202070 (CHEMBL811340) |
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Ki | 57±n/a nM |
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Citation | Huang, Y; Luedtke, RR; Freeman, RA; Wu, L; Mach, RH Synthesis and structure-activity relationships of naphthamides as dopamine D3 receptor ligands. J Med Chem44:1815-26 (2001) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Sigma non-opioid intracellular receptor 1 |
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Name: | Sigma non-opioid intracellular receptor 1 |
Synonyms: | Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 25124.85 |
Organism: | Homo sapiens (Human) |
Description: | Q99720 |
Residue: | 223 |
Sequence: | MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSR
LIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRY
WAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPS
TLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
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BDBM50099818 |
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n/a |
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Name | BDBM50099818 |
Synonyms: | 4-Bromo-1-methoxy-naphthalene-2-carboxylic acid (1-cyclohexyl-pyrrolidin-2-ylmethyl)-amide | CHEMBL52835 |
Type | Small organic molecule |
Emp. Form. | C23H29BrN2O2 |
Mol. Mass. | 445.393 |
SMILES | COc1c(cc(Br)c2ccccc12)C(=O)NC[C@@H]1CCCN1C1CCCCC1 |
Structure |
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