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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | ||
| Ligand | BDBM50006412 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEBML_80476 | ||
| IC50 | 1370±n/a nM | ||
| Citation |  Suzuki, M; Iwasaki, H; Fujikawa, Y; Sakashita, M; Kitahara, M; Sakoda, R Synthesis and biological evaluations of condensed pyridine and condensed pyrimidine-based HMG-CoA reductase inhibitors. Bioorg Med Chem Lett11:1285-8 (2001) [PubMed] | ||
| More Info.: | Get all data from this article, Assay Method | ||
| 3-hydroxy-3-methylglutaryl-coenzyme A reductase | |||
| Name: | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | ||
| Synonyms: | 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase | 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA) | HMDH_HUMAN | HMG-CoA Reductase | HMG-CoA reductase (HMGR) | HMGCR | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 97477.10 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P04035 | ||
| Residue: | 888 | ||
| Sequence: |
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| BDBM50006412 | |||
| n/a | |||
| Name | BDBM50006412 | ||
| Synonyms: | (3R,5R)-3,5-dihydroxy-7-((1S,2S,6S,8S,8aR)-6-hydroxy-2-methyl-8-((S)-2-methylbutanoyloxy)-1,2,6,7,8,8a-hexahydronaphthalen-1-yl)heptanoate sodium | 3,5-dihydroxy-7-[8-hydroxy-3-methyl-10-[1-methyl-(1S)-propylcarbonyloxy]-(1R,2S,3S,8S,10S)-bicyclo[4.4.0]deca-4,6-dien-2-yl]-(3R,5R)-sodium heptanoate | CHEMBL690 | CS-514 | Eptastatin Sodium | PRAVASTATIN SODIUM | Pravachol | Pravastatin | SQ-31000 | Sodium; (3R,5R)-3,5-dihydroxy-7-[(1S,2S,6S,8S,8aR)-6-hydroxy-2-methyl-8-((S)-2-methyl-butyryloxy)-1,2,6,7,8,8a-hexahydro-naphthalen-1-yl]-heptanoate | Sodium; 3,5-dihydroxy-7-[6-hydroxy-2-methyl-8-(2-methyl-butyryloxy)-1,2,6,7,8,8a-hexahydro-naphthalen-1-yl]-heptanoate | ||
| Type | Small organic molecule | ||
| Emp. Form. | C23H35O7 | ||
| Mol. Mass. | 423.5203 | ||
| SMILES | CC[C@H](C)C(=O)O[C@H]1C[C@@H](O)C=C2C=C[C@H](C)[C@H](CCC(O)C[C@@H](O)CC([O-])=O)[C@@H]12 |c:13,t:11| | ||
| Structure | 
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