| Reaction Details |
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 | Report a problem with these data |
| Target | Sodium channel subunit beta-2 |
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| Ligand | BDBM50257179 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1990085 (CHEMBL4623820) |
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| IC50 | 1.9±n/a nM |
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| Citation |  Shinozuka, T; Kobayashi, H; Suzuki, S; Tanaka, K; Karanjule, N; Hayashi, N; Tsuda, T; Tokumaru, E; Inoue, M; Ueda, K; Kimoto, H; Domon, Y; Takahashi, S; Kubota, K; Yokoyama, T; Shimizugawa, A; Koishi, R; Fujiwara, C; Asano, D; Sakakura, T; Takasuna, K; Abe, Y; Watanabe, T; Kitano, Y Discovery of DS-1971a, a Potent, Selective Na J Med Chem63:10204-10220 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sodium channel subunit beta-2 |
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| Name: | Sodium channel subunit beta-2 |
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| Synonyms: | SCN2B | SCN2B_HUMAN | Sodium channel subunit beta-2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 24325.09 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_119884 |
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| Residue: | 215 |
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| Sequence: | MHRDAWLPRPAFSLTGLSLFFSLVPPGRSMEVTVPATLNVLNGSDARLPCTFNSCYTVNH
KQFSLNWTYQECNNCSEEMFLQFRMKIINLKLERFQDRVEFSGNPSKYDVSVMLRNVQPE
DEGIYNCYIMNPPDRHRGHGKIHLQVLMEEPPERDSTVAVIVGASVGGFLAVVILVLMVV
KCVRRKKEQKLSTDDLKTEEEGKTDGEGNPDDGAK
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| BDBM50257179 |
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| n/a |
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| Name | BDBM50257179 |
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| Synonyms: | CHEMBL2325622 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H17ClF2N6O3S2 |
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| Mol. Mass. | 538.978 |
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| SMILES | CN1CC(C1)n1nccc1-c1cc(Cl)ccc1Oc1cc(F)c(cc1F)S(=O)(=O)Nc1ncns1 |
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| Structure | 
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