Reaction Details |
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Target | Sodium channel protein type 5 subunit alpha/subunit beta-1/subunit beta-2 |
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Ligand | BDBM258146 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1990119 (CHEMBL4623854) |
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IC50 | >100000±n/a nM |
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Citation | Shinozuka, T; Kobayashi, H; Suzuki, S; Tanaka, K; Karanjule, N; Hayashi, N; Tsuda, T; Tokumaru, E; Inoue, M; Ueda, K; Kimoto, H; Domon, Y; Takahashi, S; Kubota, K; Yokoyama, T; Shimizugawa, A; Koishi, R; Fujiwara, C; Asano, D; Sakakura, T; Takasuna, K; Abe, Y; Watanabe, T; Kitano, Y Discovery of DS-1971a, a Potent, Selective Na J Med Chem63:10204-10220 (2020) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Sodium channel protein type 5 subunit alpha/subunit beta-1/subunit beta-2 |
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Name: | Sodium channel protein type 5 subunit alpha/subunit beta-1/subunit beta-2 |
Synonyms: | Sodium channel protein type 5 subunit alpha/beta-1/beta-2 |
Type: | n/a |
Mol. Mass.: | n/a |
Description: | ASSAY_ID of ChEMBL is 1990119 |
Components: | This complex has 3 components. |
Component 1 |
Name: | Sodium channel subunit beta-1 |
Synonyms: | SCN1B_MOUSE | Scn1b | Sodium channel subunit beta-1 |
Type: | PROTEIN |
Mol. Mass.: | 24638.67 |
Organism: | Mus musculus |
Description: | ChEMBL_119885 |
Residue: | 218 |
Sequence: | MGTLLALVVGAALVSSAWGGCVEVDSDTEAVYGMTFKILCISCKRRSETTAETFTEWTFR
QKGTEEFVKILRYENEVLQLEEDERFEGRVVWNGSRGTKDLQDLSIFITNVTYNHSGDYE
CHVYRLLFFDNYEHNTSVVKKIHLEVVDKANRDMASIVSEIMMYVLIVVLTIWLVAEMVY
CYKKIAAATEAAAQENASEYLAITSESKENCTGVQVAE
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Component 2 |
Name: | Sodium channel subunit beta-2 |
Synonyms: | Gm183 | SCN2B_MOUSE | Scn2b | Sodium channel subunit beta-2 |
Type: | PROTEIN |
Mol. Mass.: | 24227.48 |
Organism: | Mus musculus |
Description: | ChEMBL_119885 |
Residue: | 215 |
Sequence: | MHRDAWLPRPAFSLTGLSLFFSLVPPGRSMEVTAPTTLSVLNGSDTRLPCTFNSCYTVNH
KQFSLNWTYQECNNCTEEMFLQFRMKIINLKLERFGDRVEFSGNPSKYDVSVTLKNVQLE
DEGIYNCYITNPPDRHRGHGKIYLQVLLEVPPERDSTVAVIVGASVGGFLAVVILVLMVV
KCVRRKKEQKLSTDDLKTEEEGKMDGEGNAEDGTK
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Component 3 |
Name: | Sodium channel protein type 5 subunit alpha |
Synonyms: | SCN5A_MOUSE | Scn5a | Sodium channel protein cardiac muscle subunit alpha | Sodium channel protein type 5 subunit alpha | Sodium channel protein type V subunit alpha | Voltage-gated sodium channel subunit alpha Nav1.5 | mH1 |
Type: | PROTEIN |
Mol. Mass.: | 227550.68 |
Organism: | Mus musculus |
Description: | ChEMBL_119883 |
Residue: | 2019 |
Sequence: | MANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSATSQESREGLPEEEAPRPQLDLQA
SKKLPDLYGNPPRELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPV
RRAAVKILVHSLFSMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARG
FCLHAFTFLRDPWNWLDFSVIVMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIV
GALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTELNGTNGSVEADGIV
WNSLDVYLNDPANYLLKNGTTDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAW
AFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQN
QATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVTNHERRSKRRK
RLSSGTEDGGDDRLPKSDSEDGPRALNQLSLTHGLSRTSMRPRSSRGSIFTFRRRDQGSE
ADFADDENSTAGESESHRTSLLVPWPLRRPSTQGQPGFGTSAPGHVLNGKRNSTVDCNGV
VSLLGAGDAEATSPGSHLLRPIVLDRPPDTTTPSEEPGGPQMLTPQAPCADGFEEPGARQ
RALSAVSVLTSALEELEESHRKCPPCWNRFAQHYLIWECCPLWMSIKQKVKFVVMDPFAD
LTITMCIVLNTLFMALEHYNMTAEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQG
WNIFDSIIVILSLMELGLSRMGNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALG
NLTLVLAIIVFIFAVVGMQLFGKNYSELRHRISDSGLLPRWHMMDFFHAFLIIFRILCGE
WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDGEMNN
LQLALARIQRGLRFVKRTTWDFCCGLLRRRPKKPAALATHSQLPSCIAAPRSPPPPEVEK
APPARKETRFEEDKRPGQGTPGDTEPVCVPIAVAESDTDDQEEDEENSLGTEEEESSKQE
SQVVSGGHEPPQEPRAWSQVSETTSSEAEASTSQADWQQEREAEPRAPGCGETPEDSYSE
GSTADMTNTADLLEQIPDLGEDVKDPEDCFTEGCVRRCPCCMVDTTQAPGKVWWRLRKTC
YRIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKW
VAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFE
GMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIV
NNKSECESFNVTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQP
QWEDNLYMYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAM
KKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKVN
ILAKINLLFVAIFTGECIVKMAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFS
PTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMAN
FAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPNLPNSNGS
RGNCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIW
EKFDPEATQFIEYLALSDFADALSEPLRIAKPNQISLINMDLPMVSGDRIHCMDILFAFT
KRVLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSATVIQRAFRRHLLQ
RSVKHASFLFRQQAGSSGLSDEDAPEREGLIAYMMNENFSRRSGPLSSSSISSTSFPPSY
DSVTRATSDNLPVRASDYSRSEDLADFPPSPDRDRESIV
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BDBM258146 |
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n/a |
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Name | BDBM258146 |
Synonyms: | US9493448, 122 | US9493448, 154 | US9493448, 48 | US9597330, Example 34 | US9845313, Example 154 |
Type | Small organic molecule |
Emp. Form. | C20H21ClFN5O3S |
Mol. Mass. | 465.929 |
SMILES | Cn1nccc1[C@H]1CCCC[C@@H]1Oc1cc(F)c(cc1Cl)S(=O)(=O)Nc1ccncn1 |r| |
Structure |
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