| Reaction Details |
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 | Report a problem with these data |
| Target | Sodium- and chloride-dependent glycine transporter 1 |
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| Ligand | BDBM50543919 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1990744 (CHEMBL4624479) |
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| IC50 | 96±n/a nM |
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| Citation |  Hudson, AR; Santora, VJ; Petroski, RE; Almos, TA; Anderson, G; Barido, R; Basinger, J; Bellows, CL; Bookser, BC; Broadbent, NJ; Cabebe, C; Chai, CK; Chen, M; Chow, S; Chung, M; Heger, L; Danks, AM; Freestone, GC; Gitnick, D; Gupta, V; Hoffmaster, C; Kaplan, AP; Kennedy, MR; Lee, D; Limberis, J; Ly, K; Mak, CC; Masatsugu, B; Morse, AC; Na, J; Neul, D; Nikpur, J; Renick, J; Sebring, K; Sevidal, S; Tabatabaei, A; Wen, J; Xia, S; Yan, Y; Yoder, ZW; Zook, D; Peters, M; Breitenbucher, JG Azetidine-based selective glycine transporter-1 (GlyT1) inhibitors with memory enhancing properties. Bioorg Med Chem Lett30:0 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sodium- and chloride-dependent glycine transporter 1 |
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| Name: | Sodium- and chloride-dependent glycine transporter 1 |
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| Synonyms: | GlyT-1 | GlyT1 | Glycine transporter 1 | SC6A9_RAT | Slc6a9 | Sodium- and chloride-dependent glycine transporter 1 | Solute carrier family 6 member 9 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 71066.17 |
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| Organism: | attus norvegicus (Rat) |
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| Description: | Glycine-1-transporter 0 HUMAN::P28572 |
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| Residue: | 638 |
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| Sequence: | MAVAHGPVATSSPEQNGAVPSEATKKDQNLTRGNWGNQIEFVLTSVGYAVGLGNVWRFPY
LCYRNGGGAFMFPYFIMLVFCGIPLFFMELSFGQFASQGCLGVWRISPMFKGVGYGMMVV
STYIGIYYNVVICIAFYYFFSSMTHVLPWAYCNNPWNTPDCAGVLDASNLTNGSRPTALS
GNLSHLFNYTLQRTSPSEEYWRLYVLKLSDDIGDFGEVRLPLLGCLGVSWVVVFLCLIRG
VKSSGKVVYFTATFPYVVLTILFVRGVTLEGAFTGIMYYLTPKWDKILEAKVWGDAASQI
FYSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSILGFMANHLGVD
VSRVADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTAIVDEV
GNEWILQKKTYVTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAASFSLVVISCIMCVSIM
YIYGHRNYFQDIQMMLGFPPPLFFQICWRFVSPTIIFFILIFTVIQYRPITYNHYQYPGW
AVAIGFLMALSSVICIPLYALFQLCRTDGDTLLQRLKNATKPSRDWGPALLEHRTGRYAP
TTTPSPEDGFEVQPLHPDKAQIPIVGSNGSSRLQDSRI
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| BDBM50543919 |
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| n/a |
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| Name | BDBM50543919 |
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| Synonyms: | CHEMBL4645731 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H22F3NO5S |
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| Mol. Mass. | 457.463 |
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| SMILES | COc1c(ccc(O[C@@H](C)C(F)(F)F)c1C(=O)N1CC(C1)c1ccccc1)S(C)(=O)=O |r| |
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| Structure | 
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