Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Indoleamine 2,3-dioxygenase 1 (Homo sapiens (Human)) | BDBM21975 ((4S)-16'-(2-aminoethyl)-9'-hydroxy-1,3,6',6'-tetra...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 41 | -43.9 | n/a | n/a | n/a | n/a | n/a | 6.5 | 37 |
University of British Columbia | Assay Description The ability of the compounds prepared in this study to inhibit purified recombinant human IDO was evaluated with a steady state spectrophotometric as... | J Med Chem 51: 2634-7 (2008) Article DOI: 10.1021/jm800143h BindingDB Entry DOI: 10.7270/Q2MK6B65 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Indoleamine 2,3-dioxygenase 1 (Homo sapiens (Human)) | BDBM50324701 (CHEMBL1221472 | Exiguamine A) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 41 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of California Curated by ChEMBL | Assay Description Inhibition of human recombinant indoleamine-2,3-dioxygenase | Nat Chem Biol 4: 535-7 (2008) Article DOI: 10.1038/nchembio.107 BindingDB Entry DOI: 10.7270/Q2P55NR5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Indoleamine 2,3-dioxygenase 1 (Homo sapiens (Human)) | BDBM50324700 (CHEMBL1221412 | Exiguamine B) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of California Curated by ChEMBL | Assay Description Inhibition of human recombinant indoleamine-2,3-dioxygenase | Nat Chem Biol 4: 535-7 (2008) Article DOI: 10.1038/nchembio.107 BindingDB Entry DOI: 10.7270/Q2P55NR5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Indoleamine 2,3-dioxygenase 1 (Homo sapiens (Human)) | BDBM50324699 (CHEMBL1221473 | Seco-exiguamine) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of California Curated by ChEMBL | Assay Description Inhibition of human recombinant indoleamine-2,3-dioxygenase | Nat Chem Biol 4: 535-7 (2008) Article DOI: 10.1038/nchembio.107 BindingDB Entry DOI: 10.7270/Q2P55NR5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Indoleamine 2,3-dioxygenase 1 (Homo sapiens (Human)) | BDBM21979 (4,7-dihydro-1H-indole-4,7-dione | Indolequinone, 1...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents | Article PubMed | 190 | -39.9 | n/a | n/a | n/a | n/a | n/a | 6.5 | 37 |
University of British Columbia | Assay Description The ability of the compounds prepared in this study to inhibit purified recombinant human IDO was evaluated with a steady state spectrophotometric as... | J Med Chem 51: 2634-7 (2008) Article DOI: 10.1021/jm800143h BindingDB Entry DOI: 10.7270/Q2MK6B65 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Indoleamine 2,3-dioxygenase 1 (Homo sapiens (Human)) | BDBM21982 (3-(2-aminoethyl)-5-(3-methyl-2,5-dioxo-1-propylimi...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 200 | -39.8 | n/a | n/a | n/a | n/a | n/a | 6.5 | 37 |
University of British Columbia | Assay Description The ability of the compounds prepared in this study to inhibit purified recombinant human IDO was evaluated with a steady state spectrophotometric as... | J Med Chem 51: 2634-7 (2008) Article DOI: 10.1021/jm800143h BindingDB Entry DOI: 10.7270/Q2MK6B65 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Indoleamine 2,3-dioxygenase 1 (Homo sapiens (Human)) | BDBM21984 (Tryptamine quinone, 25 | methyl 4-{4,7-dioxo-3-[2-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 260 | -39.1 | n/a | n/a | n/a | n/a | n/a | 6.5 | 37 |
University of British Columbia | Assay Description The ability of the compounds prepared in this study to inhibit purified recombinant human IDO was evaluated with a steady state spectrophotometric as... | J Med Chem 51: 2634-7 (2008) Article DOI: 10.1021/jm800143h BindingDB Entry DOI: 10.7270/Q2MK6B65 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Indoleamine 2,3-dioxygenase 1 (Homo sapiens (Human)) | BDBM21981 (Tryptamine quinone, 21 | methyl 4-[3-(2-{[(benzylo...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 260 | -39.1 | n/a | n/a | n/a | n/a | n/a | 6.5 | 37 |
University of British Columbia | Assay Description The ability of the compounds prepared in this study to inhibit purified recombinant human IDO was evaluated with a steady state spectrophotometric as... | J Med Chem 51: 2634-7 (2008) Article DOI: 10.1021/jm800143h BindingDB Entry DOI: 10.7270/Q2MK6B65 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Indoleamine 2,3-dioxygenase 1 (Homo sapiens (Human)) | BDBM21980 (Indolequinone, 20 | methyl 4-(4,7-dioxo-4,7-dihydr...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 420 | -37.9 | n/a | n/a | n/a | n/a | n/a | 6.5 | 37 |
University of British Columbia | Assay Description The ability of the compounds prepared in this study to inhibit purified recombinant human IDO was evaluated with a steady state spectrophotometric as... | J Med Chem 51: 2634-7 (2008) Article DOI: 10.1021/jm800143h BindingDB Entry DOI: 10.7270/Q2MK6B65 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Indoleamine 2,3-dioxygenase 1 (Homo sapiens (Human)) | BDBM21976 (Tryptamine quinone, 9 | benzyl N-[2-(4,7-dioxo-4,7...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 1.49E+3 | -34.6 | n/a | n/a | n/a | n/a | n/a | 6.5 | 37 |
University of British Columbia | Assay Description The ability of the compounds prepared in this study to inhibit purified recombinant human IDO was evaluated with a steady state spectrophotometric as... | J Med Chem 51: 2634-7 (2008) Article DOI: 10.1021/jm800143h BindingDB Entry DOI: 10.7270/Q2MK6B65 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Indoleamine 2,3-dioxygenase 1 (Homo sapiens (Human)) | BDBM21977 (Tryptamine quinone, 13 | benzyl N-{2-[5-(1,3-dioxo...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 1.09E+4 | -29.5 | n/a | n/a | n/a | n/a | n/a | 6.5 | 37 |
University of British Columbia | Assay Description The ability of the compounds prepared in this study to inhibit purified recombinant human IDO was evaluated with a steady state spectrophotometric as... | J Med Chem 51: 2634-7 (2008) Article DOI: 10.1021/jm800143h BindingDB Entry DOI: 10.7270/Q2MK6B65 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Indoleamine 2,3-dioxygenase 1 (Homo sapiens (Human)) | BDBM21973 (1-Methyltryptophan, 1 | 2-amino-3-(1-methyl-1H-ind...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 6.20E+4 | -25.0 | n/a | n/a | n/a | n/a | n/a | 6.5 | 37 |
University of British Columbia | Assay Description The ability of the compounds prepared in this study to inhibit purified recombinant human IDO was evaluated with a steady state spectrophotometric as... | J Med Chem 51: 2634-7 (2008) Article DOI: 10.1021/jm800143h BindingDB Entry DOI: 10.7270/Q2MK6B65 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium- and chloride-dependent glycine transporter 1 (Homo sapiens (Human)) | BDBM50533742 (CHEMBL4593786) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.671 | n/a | n/a | n/a | n/a | n/a | n/a |
AMRI Curated by ChEMBL | Assay Description Inhibition of glycine transporter-1B in human JAR cells assessed as reduction in [14C]glycine uptake preincubated for 10 mins followed by [14C]glycin... | J Med Chem 59: 8473-94 (2016) Article DOI: 10.1021/acs.jmedchem.6b00914 BindingDB Entry DOI: 10.7270/Q23R0XC7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium- and chloride-dependent glycine transporter 1 (Homo sapiens (Human)) | BDBM50533732 (CHEMBL4526580) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.726 | n/a | n/a | n/a | n/a | n/a | n/a |
AMRI Curated by ChEMBL | Assay Description Inhibition of glycine transporter-1B in human JAR cells assessed as reduction in [14C]glycine uptake preincubated for 10 mins followed by [14C]glycin... | J Med Chem 59: 8473-94 (2016) Article DOI: 10.1021/acs.jmedchem.6b00914 BindingDB Entry DOI: 10.7270/Q23R0XC7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium- and chloride-dependent glycine transporter 1 (Homo sapiens (Human)) | BDBM50533748 (CHEMBL4468117) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.733 | n/a | n/a | n/a | n/a | n/a | n/a |
AMRI Curated by ChEMBL | Assay Description Inhibition of glycine transporter-1B in human JAR cells assessed as reduction in [14C]glycine uptake preincubated for 10 mins followed by [14C]glycin... | J Med Chem 59: 8473-94 (2016) Article DOI: 10.1021/acs.jmedchem.6b00914 BindingDB Entry DOI: 10.7270/Q23R0XC7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bone morphogenetic protein receptor type-1B (Homo sapiens (Human)) | BDBM50262079 (4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyri...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 0.940 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea University Curated by ChEMBL | Assay Description Inhibition of human ALK6 using casein as substrate in presence of 10 uM ATP by radiometric kinase assay | J Med Chem 60: 1495-1508 (2017) Article DOI: 10.1021/acs.jmedchem.6b01679 BindingDB Entry DOI: 10.7270/Q2TQ63S4 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Sodium- and chloride-dependent glycine transporter 1 (Homo sapiens (Human)) | BDBM50533727 (CHEMBL4456392) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
AMRI Curated by ChEMBL | Assay Description Inhibition of glycine transporter-1B in human JAR cells assessed as reduction in [14C]glycine uptake preincubated for 10 mins followed by [14C]glycin... | J Med Chem 59: 8473-94 (2016) Article DOI: 10.1021/acs.jmedchem.6b00914 BindingDB Entry DOI: 10.7270/Q23R0XC7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vascular endothelial growth factor receptor 3 (Homo sapiens (Human)) | BDBM50413752 (CHEMBL2012519 | L-783277) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea University Curated by ChEMBL | Assay Description Inhibition of human FLT4 using poly[Glu:Tyr] (4:1) as substrate in presence of [gamma-33P]-ATP by scintillation counting method | J Med Chem 60: 1495-1508 (2017) Article DOI: 10.1021/acs.jmedchem.6b01679 BindingDB Entry DOI: 10.7270/Q2TQ63S4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium- and chloride-dependent glycine transporter 1 (Homo sapiens (Human)) | BDBM50533730 (CHEMBL4582587) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
AMRI Curated by ChEMBL | Assay Description Inhibition of glycine transporter-1B in human JAR cells assessed as reduction in [14C]glycine uptake preincubated for 10 mins followed by [14C]glycin... | J Med Chem 59: 8473-94 (2016) Article DOI: 10.1021/acs.jmedchem.6b00914 BindingDB Entry DOI: 10.7270/Q23R0XC7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium- and chloride-dependent glycine transporter 1 (Homo sapiens (Human)) | BDBM50533749 (CHEMBL4516089) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a |
AMRI Curated by ChEMBL | Assay Description Inhibition of glycine transporter-1B in human JAR cells assessed as reduction in [14C]glycine uptake preincubated for 10 mins followed by [14C]glycin... | J Med Chem 59: 8473-94 (2016) Article DOI: 10.1021/acs.jmedchem.6b00914 BindingDB Entry DOI: 10.7270/Q23R0XC7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium- and chloride-dependent glycine transporter 1 (Homo sapiens (Human)) | BDBM50533725 (CHEMBL4579165) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
AMRI Curated by ChEMBL | Assay Description Inhibition of glycine transporter-1B in human JAR cells assessed as reduction in [14C]glycine uptake preincubated for 10 mins followed by [14C]glycin... | J Med Chem 59: 8473-94 (2016) Article DOI: 10.1021/acs.jmedchem.6b00914 BindingDB Entry DOI: 10.7270/Q23R0XC7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium- and chloride-dependent glycine transporter 1 (Homo sapiens (Human)) | BDBM50533723 (CHEMBL4572086) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
AMRI Curated by ChEMBL | Assay Description Inhibition of glycine transporter-1B in human JAR cells assessed as reduction in [14C]glycine uptake preincubated for 10 mins followed by [14C]glycin... | J Med Chem 59: 8473-94 (2016) Article DOI: 10.1021/acs.jmedchem.6b00914 BindingDB Entry DOI: 10.7270/Q23R0XC7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human)) | BDBM50413752 (CHEMBL2012519 | L-783277) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea University Curated by ChEMBL | Assay Description Inhibition of human FLT3 using EAIYAAPFAKKK peptide as substrate in presence of [gamma-33P]-ATP by scintillation counting method | J Med Chem 60: 1495-1508 (2017) Article DOI: 10.1021/acs.jmedchem.6b01679 BindingDB Entry DOI: 10.7270/Q2TQ63S4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone acetyltransferase KAT6A [507-778] (Homo sapiens) | BDBM50518833 (CHEMBL4528993 | US10829446, Compound 45) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Cancer Therapeutics CRC Curated by ChEMBL | Assay Description Inhibition of N-terminal NusA-fused His6-tagged human KAT6A (507 to 778 residues) expressed in Escherichia coli BL21 (DE3) cells using 0.4 uM acetyl ... | J Med Chem 62: 7146-7159 (2019) Article DOI: 10.1021/acs.jmedchem.9b00665 BindingDB Entry DOI: 10.7270/Q26D5XCM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium- and chloride-dependent glycine transporter 1 (attus norvegicus (Rat)) | BDBM50457704 (CHEMBL4202565) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Dart NeuroScience LLC Curated by ChEMBL | Assay Description Inhibition of GlyT1 in primary rat cortical neurons assessed as reduction in [14C]glycine uptake after 2 hrs by microbeta scintillation counting meth... | J Med Chem 61: 6018-6033 (2018) Article DOI: 10.1021/acs.jmedchem.8b00372 BindingDB Entry DOI: 10.7270/Q2GB26PM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium- and chloride-dependent glycine transporter 1 (Homo sapiens (Human)) | BDBM50533736 (CHEMBL4462009) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2.10 | n/a | n/a | n/a | n/a | n/a | n/a |
AMRI Curated by ChEMBL | Assay Description Inhibition of glycine transporter-1B in human JAR cells assessed as reduction in [14C]glycine uptake preincubated for 10 mins followed by [14C]glycin... | J Med Chem 59: 8473-94 (2016) Article DOI: 10.1021/acs.jmedchem.6b00914 BindingDB Entry DOI: 10.7270/Q23R0XC7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bone morphogenetic protein receptor type-1A (Homo sapiens (Human)) | BDBM50262079 (4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyri...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 2.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea University Curated by ChEMBL | Assay Description Inhibition of human ALK3 using casein as substrate in presence of 10 uM ATP by radiometric kinase assay | J Med Chem 60: 1495-1508 (2017) Article DOI: 10.1021/acs.jmedchem.6b01679 BindingDB Entry DOI: 10.7270/Q2TQ63S4 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Sodium- and chloride-dependent glycine transporter 1 (Homo sapiens (Human)) | BDBM50533733 (CHEMBL4532784) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a |
AMRI Curated by ChEMBL | Assay Description Inhibition of glycine transporter-1B in human JAR cells assessed as reduction in [14C]glycine uptake preincubated for 10 mins followed by [14C]glycin... | J Med Chem 59: 8473-94 (2016) Article DOI: 10.1021/acs.jmedchem.6b00914 BindingDB Entry DOI: 10.7270/Q23R0XC7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium- and chloride-dependent glycine transporter 1 (attus norvegicus (Rat)) | BDBM50457706 (CHEMBL4216391) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Dart NeuroScience LLC Curated by ChEMBL | Assay Description Inhibition of GlyT1 in primary rat cortical neurons assessed as reduction in [14C]glycine uptake after 2 hrs by microbeta scintillation counting meth... | J Med Chem 61: 6018-6033 (2018) Article DOI: 10.1021/acs.jmedchem.8b00372 BindingDB Entry DOI: 10.7270/Q2GB26PM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium- and chloride-dependent glycine transporter 1 (attus norvegicus (Rat)) | BDBM50457693 (CHEMBL4218366) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Dart NeuroScience LLC Curated by ChEMBL | Assay Description Inhibition of GlyT1 in primary rat cortical neurons assessed as reduction in [14C]glycine uptake after 2 hrs by microbeta scintillation counting meth... | J Med Chem 61: 6018-6033 (2018) Article DOI: 10.1021/acs.jmedchem.8b00372 BindingDB Entry DOI: 10.7270/Q2GB26PM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent serotonin transporter (Homo sapiens (Human)) | BDBM30130 (CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem Patents Similars | DrugBank Article PubMed | n/a | n/a | 3.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Institute of Science and Technology Curated by ChEMBL | Assay Description Inhibition of serotonin reuptake at human SERT expressed in HEK293 cells | Bioorg Med Chem Lett 20: 5567-71 (2010) Article DOI: 10.1016/j.bmcl.2010.07.021 BindingDB Entry DOI: 10.7270/Q24F1RQ7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Activin receptor type-1 (Homo sapiens (Human)) | BDBM50262079 (4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyri...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 3.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea University Curated by ChEMBL | Assay Description Inhibition of human ALK2 using casein as substrate in presence of 10 uM ATP by radiometric kinase assay | J Med Chem 60: 1495-1508 (2017) Article DOI: 10.1021/acs.jmedchem.6b01679 BindingDB Entry DOI: 10.7270/Q2TQ63S4 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Sodium- and chloride-dependent glycine transporter 1 (attus norvegicus (Rat)) | BDBM50457695 (CHEMBL4217712) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Dart NeuroScience LLC Curated by ChEMBL | Assay Description Inhibition of GlyT1 in primary rat cortical neurons assessed as reduction in [14C]glycine uptake after 2 hrs by microbeta scintillation counting meth... | J Med Chem 61: 6018-6033 (2018) Article DOI: 10.1021/acs.jmedchem.8b00372 BindingDB Entry DOI: 10.7270/Q2GB26PM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium- and chloride-dependent glycine transporter 1 (attus norvegicus (Rat)) | BDBM50457685 (CHEMBL4210484) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Dart NeuroScience LLC Curated by ChEMBL | Assay Description Inhibition of GlyT1 in primary rat cortical neurons assessed as reduction in [14C]glycine uptake after 2 hrs by microbeta scintillation counting meth... | J Med Chem 61: 6018-6033 (2018) Article DOI: 10.1021/acs.jmedchem.8b00372 BindingDB Entry DOI: 10.7270/Q2GB26PM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium- and chloride-dependent glycine transporter 1 (attus norvegicus (Rat)) | BDBM50457694 (CHEMBL4211535) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Dart NeuroScience LLC Curated by ChEMBL | Assay Description Inhibition of GlyT1 in primary rat cortical neurons assessed as reduction in [14C]glycine uptake after 2 hrs by microbeta scintillation counting meth... | J Med Chem 61: 6018-6033 (2018) Article DOI: 10.1021/acs.jmedchem.8b00372 BindingDB Entry DOI: 10.7270/Q2GB26PM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium- and chloride-dependent glycine transporter 1 (Homo sapiens (Human)) | BDBM50457704 (CHEMBL4202565) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Dart NeuroScience LLC Curated by ChEMBL | Assay Description Inhibition of recombinant human GlyT1c expressed in HEK293 cells assessed as reduction in [14C]glycine uptake after 2 hrs by microbeta scintillation ... | J Med Chem 61: 6018-6033 (2018) Article DOI: 10.1021/acs.jmedchem.8b00372 BindingDB Entry DOI: 10.7270/Q2GB26PM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium- and chloride-dependent glycine transporter 1 (attus norvegicus (Rat)) | BDBM50457692 (CHEMBL4211012) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Dart NeuroScience LLC Curated by ChEMBL | Assay Description Inhibition of GlyT1 in primary rat cortical neurons assessed as reduction in [14C]glycine uptake after 2 hrs by microbeta scintillation counting meth... | J Med Chem 61: 6018-6033 (2018) Article DOI: 10.1021/acs.jmedchem.8b00372 BindingDB Entry DOI: 10.7270/Q2GB26PM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium- and chloride-dependent glycine transporter 1 (attus norvegicus (Rat)) | BDBM50457689 (CHEMBL4206403) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Dart NeuroScience LLC Curated by ChEMBL | Assay Description Inhibition of GlyT1 in primary rat cortical neurons assessed as reduction in [14C]glycine uptake after 2 hrs by microbeta scintillation counting meth... | J Med Chem 61: 6018-6033 (2018) Article DOI: 10.1021/acs.jmedchem.8b00372 BindingDB Entry DOI: 10.7270/Q2GB26PM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium- and chloride-dependent glycine transporter 1 (Homo sapiens (Human)) | BDBM50427184 (CHEMBL2324479) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 4.40 | n/a | n/a | n/a | n/a | n/a | n/a |
AMRI Curated by ChEMBL | Assay Description Inhibition of GlyT1a in human JAR cells assessed as inhibition of [3H]glycine uptake by scintillation proximity assay | Bioorg Med Chem Lett 23: 1257-61 (2013) Article DOI: 10.1016/j.bmcl.2013.01.006 BindingDB Entry DOI: 10.7270/Q2WH2RB6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone acetyltransferase KAT6A [507-778] (Homo sapiens) | BDBM50527224 (CHEMBL4468833 | US10829446, Compound 48) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Monash University (Parkville Campus) Curated by ChEMBL | Assay Description Inhibition of N-terminal NusA-fused His6-tagged human KAT6A (507 to 778 residues) expressed in Escherichia coli BL21 (DE3) cells using 0.4 uM acetyl ... | J Med Chem 63: 4655-4684 (2020) Article DOI: 10.1021/acs.jmedchem.9b02071 BindingDB Entry DOI: 10.7270/Q2W66Q7V | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium- and chloride-dependent glycine transporter 1 (attus norvegicus (Rat)) | BDBM50543922 (CHEMBL4640428) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 5.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Dart Neuroscience Curated by ChEMBL | Assay Description Inhibition of GlyT1 in rat primary cortical neurons assessed as reduction in radiolabeled glycine uptake by scintillation proximity assay | Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2020.127214 BindingDB Entry DOI: 10.7270/Q29027C0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium- and chloride-dependent glycine transporter 1 (Homo sapiens (Human)) | BDBM50533752 (CHEMBL4573115) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 5.10 | n/a | n/a | n/a | n/a | n/a | n/a |
AMRI Curated by ChEMBL | Assay Description Inhibition of glycine transporter-1B in human JAR cells assessed as reduction in [14C]glycine uptake preincubated for 10 mins followed by [14C]glycin... | J Med Chem 59: 8473-94 (2016) Article DOI: 10.1021/acs.jmedchem.6b00914 BindingDB Entry DOI: 10.7270/Q23R0XC7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium- and chloride-dependent glycine transporter 1 (Homo sapiens (Human)) | BDBM50533743 (CHEMBL4555741) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 5.10 | n/a | n/a | n/a | n/a | n/a | n/a |
AMRI Curated by ChEMBL | Assay Description Inhibition of glycine transporter-1B in human JAR cells assessed as reduction in [14C]glycine uptake preincubated for 10 mins followed by [14C]glycin... | J Med Chem 59: 8473-94 (2016) Article DOI: 10.1021/acs.jmedchem.6b00914 BindingDB Entry DOI: 10.7270/Q23R0XC7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium- and chloride-dependent glycine transporter 1 (Homo sapiens (Human)) | BDBM50533734 (CHEMBL4439865) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 5.30 | n/a | n/a | n/a | n/a | n/a | n/a |
AMRI Curated by ChEMBL | Assay Description Inhibition of glycine transporter-1B in human JAR cells assessed as reduction in [14C]glycine uptake preincubated for 10 mins followed by [14C]glycin... | J Med Chem 59: 8473-94 (2016) Article DOI: 10.1021/acs.jmedchem.6b00914 BindingDB Entry DOI: 10.7270/Q23R0XC7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone acetyltransferase KAT6A [507-778] (Homo sapiens) | BDBM50527244 (CHEMBL4437798 | US10829446, Compound 105) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 5.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Monash University (Parkville Campus) Curated by ChEMBL | Assay Description Inhibition of N-terminal NusA-fused His6-tagged human KAT6A (507 to 778 residues) expressed in Escherichia coli BL21 (DE3) cells using 0.4 uM acetyl ... | J Med Chem 63: 4655-4684 (2020) Article DOI: 10.1021/acs.jmedchem.9b02071 BindingDB Entry DOI: 10.7270/Q2W66Q7V | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium- and chloride-dependent glycine transporter 1 (Homo sapiens (Human)) | BDBM50533750 (CHEMBL4475426) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 5.60 | n/a | n/a | n/a | n/a | n/a | n/a |
AMRI Curated by ChEMBL | Assay Description Inhibition of glycine transporter-1B in human JAR cells assessed as reduction in [14C]glycine uptake preincubated for 10 mins followed by [14C]glycin... | J Med Chem 59: 8473-94 (2016) Article DOI: 10.1021/acs.jmedchem.6b00914 BindingDB Entry DOI: 10.7270/Q23R0XC7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium- and chloride-dependent glycine transporter 1 (Homo sapiens (Human)) | BDBM50457703 (CHEMBL4214250) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Dart NeuroScience LLC Curated by ChEMBL | Assay Description Inhibition of recombinant human GlyT1c expressed in HEK293 cells assessed as reduction in [14C]glycine uptake after 2 hrs by microbeta scintillation ... | J Med Chem 61: 6018-6033 (2018) Article DOI: 10.1021/acs.jmedchem.8b00372 BindingDB Entry DOI: 10.7270/Q2GB26PM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone acetyltransferase KAT6A [507-778] (Homo sapiens) | BDBM50527381 (CHEMBL4466823 | US10829446, Compound 41) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Monash University (Parkville Campus) Curated by ChEMBL | Assay Description Inhibition of N-terminal NusA-fused His6-tagged human KAT6A (507 to 778 residues) expressed in Escherichia coli BL21 (DE3) cells using 0.4 uM acetyl ... | J Med Chem 63: 4655-4684 (2020) Article DOI: 10.1021/acs.jmedchem.9b02071 BindingDB Entry DOI: 10.7270/Q2W66Q7V | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium- and chloride-dependent glycine transporter 1 (Homo sapiens (Human)) | BDBM50427183 (CHEMBL2324480) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 6.10 | n/a | n/a | n/a | n/a | n/a | n/a |
AMRI Curated by ChEMBL | Assay Description Inhibition of GlyT1a in human JAR cells assessed as inhibition of [3H]glycine uptake by scintillation proximity assay | Bioorg Med Chem Lett 23: 1257-61 (2013) Article DOI: 10.1016/j.bmcl.2013.01.006 BindingDB Entry DOI: 10.7270/Q2WH2RB6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human)) | BDBM50413752 (CHEMBL2012519 | L-783277) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 6.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea University Curated by ChEMBL | Assay Description Inhibition of human KDR using poly[Glu:Tyr] (4:1) as substrate in presence of [gamma-33P]-ATP by scintillation counting method | J Med Chem 60: 1495-1508 (2017) Article DOI: 10.1021/acs.jmedchem.6b01679 BindingDB Entry DOI: 10.7270/Q2TQ63S4 | |||||||||||
More data for this Ligand-Target Pair |
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