| Reaction Details |
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 | Report a problem with these data |
| Target | Acyl-protein thioesterase 1 |
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| Ligand | BDBM50050513 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1990947 (CHEMBL4624682) |
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| IC50 | 224±n/a nM |
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| Citation |  Zhang, B; Liu, F; Yang, MF; Xu, J; Wang, Z; Zhang, J; Wang, R; Yang, X A cell-based fluorescent assay for FAP inhibitor discovery. Bioorg Med Chem Lett30:0 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Acyl-protein thioesterase 1 |
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| Name: | Acyl-protein thioesterase 1 |
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| Synonyms: | Acyl-protein thioesterase 1/2 | Apt1 | LYPA1_RAT | Lypla1 | Lysosomal phospholipase A1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 24708.49 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_12731 |
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| Residue: | 230 |
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| Sequence: | MCGNNMSAPMPAVVPAARKATAAVIFLHGLGDTGHGWAEAFAGIKSSHIKYICPHAPVMP
VTLNMSMMMPSWFDIIGLSPDSQEDESGIKQAAETVKALIDQEVKNGIPSNRIILGGFSQ
GGALSLYTALTTQQKLAGVTALSCWLPLRASFSQGPINSANRDISVLQCHGDCDPLVPLM
FGSLTVERLKGLVNPANVTFKVYEGMMHSSCQQEMMDVKYFIDKLLPPID
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| BDBM50050513 |
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| n/a |
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| Name | BDBM50050513 |
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| Synonyms: | (R)-1-((S)-2-amino-3-methylbutanoyl)pyrrolidin-2-ylboronic acid | (S)-2-Amino-1-((R)-2-dihydroxyboron-pyrrolidin-1-yl)-3-methyl-butan-1-one | (S)-2-Amino-3-methyl-2-boronic acid-1-pyrrolidin-1-yl-butan-1-one | Boronic acid derivative | CHEMBL67279 | Ketopyrrolidine derivative | Pyrrolidine derivative | US11096924, DASH-inhibitors 2504 C | US11504364, Compound Val-boroPro | US11559537, Compound 2054-Val-boro-Pro | US11707539, Compound 2054 |
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| Type | Small organic molecule |
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| Emp. Form. | C9H19BN2O3 |
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| Mol. Mass. | 214.07 |
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| SMILES | CC(C)[C@H](N)C(=O)N1CCC[C@H]1B(O)O |r| |
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| Structure | 
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