| Reaction Details |
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 | Report a problem with these data |
| Target | Substance-P receptor |
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| Ligand | BDBM50101032 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_205726 |
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| IC50 | 3.5±n/a nM |
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| Citation |  Fritz, JE; Hipskind, PA; Lobb, KL; Nixon, JA; Threlkeld, PG; Gitter, BD; McMillian, CL; Kaldor, SW Expedited discovery of second generation NK-1 antagonists: identification of a nonbasic aryloxy substituent. Bioorg Med Chem Lett11:1643-6 (2001) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Substance-P receptor |
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| Name: | Substance-P receptor |
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| Synonyms: | NK-1 receptor | NK-1R | NK1 Receptor | NK1R | NK1R_HUMAN | Neurokinin 1 receptor | Neurokinin-1 (NK-1) | Neuromedin-1 receptor (NK-1R) | SPR | TAC1R | TACR1 | Tachykinin receptor 1 | Tachykinin receptor 1 (NK1) | tachykinin |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 46254.43 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P25103 |
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| Residue: | 407 |
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| Sequence: | MDNVLPVDSDLSPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAH
KRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASI
YSMTAVAFDRYMAIIHPLQPRLSATATKVVICVIWVLALLLAFPQGYYSTTETMPSRVVC
MIEWPEHPNKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQV
SAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMSSTMY
NPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQGSVYKVSRLETTIST
VVGAHEEEPEDGPKATPSSLDLTSNCSSRSDSKTMTESFSFSSNVLS
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| BDBM50101032 |
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| n/a |
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| Name | BDBM50101032 |
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| Synonyms: | 1N-{2-(1H-3-indolyl)-1-[2-methoxybenzyl(methyl)carboxamidomethyl]ethyl}-2-(4-acetylphenoxy)acetamide | CHEMBL42597 |
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| Type | Small organic molecule |
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| Emp. Form. | C31H33N3O5 |
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| Mol. Mass. | 527.6108 |
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| SMILES | COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)COc1ccc(cc1)C(C)=O)C(C)=O |
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| Structure | 
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