| Reaction Details |
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 | Report a problem with these data |
| Target | DNA (cytosine-5)-methyltransferase 3A |
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| Ligand | BDBM50544058 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1991440 (CHEMBL4625175) |
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| Kd | 1300±n/a nM |
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| Citation |  Sergeev, A; Vorobyov, A; Yakubovskaya, M; Kirsanova, O; Gromova, E Novel anticancer drug curaxin CBL0137 impairs DNA methylation by eukaryotic DNA methyltransferase Dnmt3a. Bioorg Med Chem Lett30:0 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| DNA (cytosine-5)-methyltransferase 3A |
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| Name: | DNA (cytosine-5)-methyltransferase 3A |
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| Synonyms: | 2.1.1.- | 2.1.1.37 | Cysteine methyltransferase DNMT3A | DNA (cytosine-5)-methyltransferase 3A | DNA MTase MmuIIIA | DNA methyltransferase MmuIIIA | DNM3A_MOUSE | Dnmt3a |
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| Type: | PROTEIN |
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| Mol. Mass.: | 101671.89 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_108012 |
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| Residue: | 908 |
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| Sequence: | MPSSGPGDTSSSSLEREDDRKEGEEQEENRGKEERQEPSATARKVGRPGRKRKHPPVESS
DTPKDPAVTTKSQPMAQDSGPSDLLPNGDLEKRSEPQPEEGSPAAGQKGGAPAEGEGTET
PPEASRAVENGCCVTKEGRGASAGEGKEQKQTNIESMKMEGSRGRLRGGLGWESSLRQRP
MPRLTFQAGDPYYISKRKRDEWLARWKREAEKKAKVIAVMNAVEENQASGESQKVEEASP
PAVQQPTDPASPTVATTPEPVGGDAGDKNATKAADDEPEYEDGRGFGIGELVWGKLRGFS
WWPGRIVSWWMTGRSRAAEGTRWVMWFGDGKFSVVCVEKLMPLSSFCSAFHQATYNKQPM
YRKAIYEVLQVASSRAGKLFPACHDSDESDSGKAVEVQNKQMIEWALGGFQPSGPKGLEP
PEEEKNPYKEVYTDMWVEPEAAAYAPPPPAKKPRKSTTEKPKVKEIIDERTRERLVYEVR
QKCRNIEDICISCGSLNVTLEHPLFIGGMCQNCKNCFLECAYQYDDDGYQSYCTICCGGR
EVLMCGNNNCCRCFCVECVDLLVGPGAAQAAIKEDPWNCYMCGHKGTYGLLRRREDWPSR
LQMFFANNHDQEFDPPKVYPPVPAEKRKPIRVLSLFDGIATGLLVLKDLGIQVDRYIASE
VCEDSITVGMVRHQGKIMYVGDVRSVTQKHIQEWGPFDLVIGGSPCNDLSIVNPARKGLY
EGTGRLFFEFYRLLHDARPKEGDDRPFFWLFENVVAMGVSDKRDISRFLESNPVMIDAKE
VSAAHRARYFWGNLPGMNRPLASTVNDKLELQECLEHGRIAKFSKVRTITTRSNSIKQGK
DQHFPVFMNEKEDILWCTEMERVFGFPVHYTDVSNMSRLARQRLLGRSWSVPVIRHLFAP
LKEYFACV
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| BDBM50544058 |
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| n/a |
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| Name | BDBM50544058 |
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| Synonyms: | CHEMBL4640631 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H24N2O2 |
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| Mol. Mass. | 336.4275 |
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| SMILES | CC(C)NCCn1c2ccc(cc2c2cc(ccc12)C(C)=O)C(C)=O |
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| Structure | 
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