| Reaction Details |
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 | Report a problem with these data |
| Target | TYR_PHOSPHATASE_2 domain-containing protein |
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| Ligand | BDBM50544442 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1992590 (CHEMBL4626325) |
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| IC50 | 9100±n/a nM |
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| Citation |  Ruddraraju, KV; Aggarwal, D; Niu, C; Baker, EA; Zhang, RY; Wu, L; Zhang, ZY Highly Potent and Selective J Med Chem63:9212-9227 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| TYR_PHOSPHATASE_2 domain-containing protein |
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| Name: | TYR_PHOSPHATASE_2 domain-containing protein |
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| Synonyms: | (PROTEIN-TYROSINE-PHOSPHATASE) (PTPase) | MPtpB | PHOSPHOTYROSINE PROTEIN PHOSPHATASE PTPB | Phosphotyrosine protein phosphatase | Phosphotyrosine-protein phosphatase PTPB | Protein Tyrosine Phosphatase PTPB |
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| Type: | Hydrolase |
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| Mol. Mass.: | 30152.45 |
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| Organism: | Mycobacterium tuberculosis |
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| Description: | n/a |
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| Residue: | 276 |
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| Sequence: | MAVRELPGAWNFRDVADTATALRPGRLFRSSELSRLDDAGRATLRRLGITDVADLRSSRE
VARRGPGRVPDGIDVHLLPFPDLADDDADDSAPHETAFKRLLTNDGSNGESGESSQSIND
AATRYMTDEYRQFPTRNGAQRALHRVVTLLAAGRPVLTHCFAGKDRTGFVVALVLEAVGL
DRDVIVADYLRSNDSVPQLRARISEMIQQRFDTELAPEVVTFTKARLSDGVLGVRAEYLA
AARQTIDETYGSLGGYLRDAGISQATVNRMRGVLLG
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| BDBM50544442 |
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| n/a |
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| Name | BDBM50544442 |
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| Synonyms: | CHEMBL4638011 | US11192850, Entry 4v |
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| Type | Small organic molecule |
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| Emp. Form. | C17H9F4NO3 |
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| Mol. Mass. | 351.2519 |
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| SMILES | OC(=O)C(=O)Nc1ccc(cc1)C#Cc1ccc(cc1F)C(F)(F)F |
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| Structure | 
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