| Reaction Details |
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 | Report a problem with these data |
| Target | Dual specificity protein phosphatase 10 |
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| Ligand | BDBM50544440 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1992570 (CHEMBL4626305) |
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| IC50 | >30000±n/a nM |
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| Citation |  Ruddraraju, KV; Aggarwal, D; Niu, C; Baker, EA; Zhang, RY; Wu, L; Zhang, ZY Highly Potent and Selective J Med Chem63:9212-9227 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dual specificity protein phosphatase 10 |
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| Name: | Dual specificity protein phosphatase 10 |
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| Synonyms: | DUS10_HUMAN | DUSP10 | Dual specificity protein phosphatase 10 | MAP kinase phosphatase 5 | MKP-5 | MKP5 | Mitogen-activated protein kinase phosphatase 5 | Mitogen-activated protein kinase phosphatase 5 (MKP5) |
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| Type: | Enzyme |
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| Mol. Mass.: | 52649.12 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9Y6W6 |
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| Residue: | 482 |
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| Sequence: | MPPSPLDDRVVVALSRPVRPQDLNLCLDSSYLGSANPGSNSHPPVIATTVVSLKAANLTY
MPSSSGSARSLNCGCSSASCCTVATYDKDNQAQTQAIAAGTTTTAIGTSTTCPANQMVNN
NENTGSLSPSSGVGSPVSGTPKQLASIKIIYPNDLAKKMTKCSKSHLPSQGPVIIDCRPF
MEYNKSHIQGAVHINCADKISRRRLQQGKITVLDLISCREGKDSFKRIFSKEIIVYDENT
NEPSRVMPSQPLHIVLESLKREGKEPLVLKGGLSSFKQNHENLCDNSLQLQECREVGGGA
SAASSLLPQPIPTTPDIENAELTPILPFLFLGNEQDAQDLDTMQRLNIGYVINVTTHLPL
YHYEKGLFNYKRLPATDSNKQNLRQYFEEAFEFIEEAHQCGKGLLIHCQAGVSRSATIVI
AYLMKHTRMTMTDAYKFVKGKRPIISPNLNFMGQLLEFEEDLNNGVTPRILTPKLMGVET
VV
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| BDBM50544440 |
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| n/a |
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| Name | BDBM50544440 |
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| Synonyms: | CHEMBL4647367 | US11192850, Entry 4t |
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| Type | Small organic molecule |
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| Emp. Form. | C17H9ClF3NO3 |
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| Mol. Mass. | 367.706 |
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| SMILES | OC(=O)C(=O)Nc1ccc(cc1)C#Cc1ccc(cc1Cl)C(F)(F)F |
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| Structure | 
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