| Reaction Details |
|---|
 | Report a problem with these data |
| Target | TYR_PHOSPHATASE_2 domain-containing protein |
|---|
| Ligand | BDBM50544441 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1992584 (CHEMBL4626319) |
|---|
| Ki | 1.2±n/a nM |
|---|
| Citation |  Ruddraraju, KV; Aggarwal, D; Niu, C; Baker, EA; Zhang, RY; Wu, L; Zhang, ZY Highly Potent and Selective J Med Chem63:9212-9227 (2020) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| TYR_PHOSPHATASE_2 domain-containing protein |
|---|
| Name: | TYR_PHOSPHATASE_2 domain-containing protein |
|---|
| Synonyms: | (PROTEIN-TYROSINE-PHOSPHATASE) (PTPase) | MPtpB | PHOSPHOTYROSINE PROTEIN PHOSPHATASE PTPB | Phosphotyrosine protein phosphatase | Phosphotyrosine-protein phosphatase PTPB | Protein Tyrosine Phosphatase PTPB |
|---|
| Type: | Hydrolase |
|---|
| Mol. Mass.: | 30152.45 |
|---|
| Organism: | Mycobacterium tuberculosis |
|---|
| Description: | n/a |
|---|
| Residue: | 276 |
|---|
| Sequence: | MAVRELPGAWNFRDVADTATALRPGRLFRSSELSRLDDAGRATLRRLGITDVADLRSSRE
VARRGPGRVPDGIDVHLLPFPDLADDDADDSAPHETAFKRLLTNDGSNGESGESSQSIND
AATRYMTDEYRQFPTRNGAQRALHRVVTLLAAGRPVLTHCFAGKDRTGFVVALVLEAVGL
DRDVIVADYLRSNDSVPQLRARISEMIQQRFDTELAPEVVTFTKARLSDGVLGVRAEYLA
AARQTIDETYGSLGGYLRDAGISQATVNRMRGVLLG
|
|
|
|---|
| BDBM50544441 |
|---|
| n/a |
|---|
| Name | BDBM50544441 |
|---|
| Synonyms: | CHEMBL4637373 | US11192850, Entry 4u |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C17H9BrF3NO3 |
|---|
| Mol. Mass. | 412.157 |
|---|
| SMILES | OC(=O)C(=O)Nc1ccc(cc1)C#Cc1ccc(cc1Br)C(F)(F)F |
|---|
| Structure | 
|
|---|
Search and Browse
