| Reaction Details |
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 | Report a problem with these data |
| Target | Phospholipase A and acyltransferase 5 |
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| Ligand | BDBM50544583 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1993180 (CHEMBL4626915) |
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| IC50 | 40±n/a nM |
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| Citation |  Zhou, J; Mock, ED; Al Ayed, K; Di, X; Kantae, V; Burggraaff, L; Stevens, AF; Martella, A; Mohr, F; Jiang, M; van der Wel, T; Wendel, TJ; Ofman, TP; Tran, Y; de Koster, N; van Westen, GJP; Hankemeier, T; van der Stelt, M Structure-Activity Relationship Studies of ?-Ketoamides as Inhibitors of the Phospholipase A and Acyltransferase Enzyme Family. J Med Chem63:9340-9359 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Phospholipase A and acyltransferase 5 |
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| Name: | Phospholipase A and acyltransferase 5 |
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| Synonyms: | 2.3.1.- | 3.1.1.32 | 3.1.1.4 | Ca(2+)-independent N-acyltransferase | H-rev107-like protein 5 | HRAS-like suppressor 5 | HRASLS5 | HRLP5 | HRSL5 | PLAAT5 | PLAT5_HUMAN | Phospholipase A and acyltransferase 5 | iNAT |
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| Type: | PROTEIN |
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| Mol. Mass.: | 30316.43 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_119943 |
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| Residue: | 279 |
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| Sequence: | MGLSPGAEGEYALRLPRIPPPLPKPASRTASTGPKDQPPALRRSAVPHSGLNSISPLELE
ESVGFAALVQLPAKQPPPGTLEQGRSIQQGEKAVVSLETTPSQKADWSSIPKPENEGKLI
KQAAEGKPRPRPGDLIEIFRIGYEHWAIYVEDDCVVHLAPPSEEFEVGSITSIFSNRAVV
KYSRLEDVLHGCSWKVNNKLDGTYLPLPVDKIIQRTKKMVNKIVQYSLIEGNCEHFVNGL
RYGVPRSQQVEHALMEGAKAAGAVISAVVDSIKPKPITA
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| BDBM50544583 |
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| n/a |
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| Name | BDBM50544583 |
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| Synonyms: | CHEMBL4639242 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H23NO2 |
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| Mol. Mass. | 309.4021 |
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| SMILES | Cc1ccc(CCNC(=O)C(=O)CCCc2ccccc2)cc1 |
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| Structure | 
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