Reaction Details |
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Target | Prostacyclin receptor |
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Ligand | BDBM50101853 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_158468 |
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Ki | 150±n/a nM |
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Citation | Maruyama, T; Asada, M; Shiraishi, T; Ishida, A; Egashira, H; Yoshida, H; Maruyama, T; Ohuchida, S; Nakai, H; Kondo, K; Toda, M Design and synthesis of a highly selective EP4-receptor agonist. Part 1: 3,7-dithiaPG derivatives with high selectivity. Bioorg Med Chem Lett11:2029-31 (2001) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Prostacyclin receptor |
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Name: | Prostacyclin receptor |
Synonyms: | PGI receptor | PI2R_HUMAN | PRIPR | PTGIR | Prostacyclin (IP) Receptor | Prostacyclin receptor | Prostaglandin I | Prostaglandin I2 | Prostaglandin I2 receptor | Prostanoid IP receptor |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 40968.22 |
Organism: | Homo sapiens (Human) |
Description: | The membranes prepared from human platelet were used in binding assay. |
Residue: | 386 |
Sequence: | MADSCRNLTYVRGSVGPATSTLMFVAGVVGNGLALGILSARRPARPSAFAVLVTGLAATD
LLGTSFLSPAVFVAYARNSSLLGLARGGPALCDAFAFAMTFFGLASMLILFAMAVERCLA
LSHPYLYAQLDGPRCARLALPAIYAFCVLFCALPLLGLGQHQQYCPGSWCFLRMRWAQPG
GAAFSLAYAGLVALLVAAIFLCNGSVTLSLCRMYRQQKRHQGSLGPRPRTGEDEVDHLIL
LALMTVVMAVCSLPLTIRCFTQAVAPDSSSEMGDLLAFRFYAFNPILDPWVFILFRKAVF
QRLKLWVCCLCLGPAHGDSQTPLSQLASGRRDPRAPSAPVGKEGSCVPLSAWGEGQVEPL
PPTQQSSGSAVGTSSKAEASVACSLC
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BDBM50101853 |
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n/a |
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Name | BDBM50101853 |
Synonyms: | (11alpha,13E,15S)-11,15-dihydroxy-9-oxoprost-13-en-1-oic acid | (13E,15S)-11alpha,15-dihydroxy-9-oxoprost-13-en-1-oic acid | 11alpha,15alpha-dihydroxy-9-oxo-13-trans-prostenoic acid | ALPROSTADIL | CHEMBL495 | PGE-1 | PGE1 | prostaglandin E1 |
Type | Small organic molecule |
Emp. Form. | C20H34O5 |
Mol. Mass. | 354.481 |
SMILES | CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(O)=O |r| |
Structure |
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