| Reaction Details |
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 | Report a problem with these data |
| Target | RNA-directed RNA polymerase |
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| Ligand | BDBM235879 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1994248 (CHEMBL4628143) |
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| EC50 | 1.4±n/a nM |
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| Citation |  Xiao, D; Dai, X; Liu, H; He, S; Shi, ZC; Ludmerer, SW; Li, F; Nargund, R; Palani, A Multi-step parallel synthesis enabled optimization of benzofuran derivatives as pan-genotypic non-nucleoside inhibitors of HCV NS5B. Bioorg Med Chem Lett30:0 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| RNA-directed RNA polymerase |
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| Name: | RNA-directed RNA polymerase |
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| Synonyms: | Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein |
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| Type: | Protein |
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| Mol. Mass.: | 25173.95 |
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| Organism: | Hepatitis C virus |
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| Description: | Q8JXU8 |
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| Residue: | 229 |
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| Sequence: | RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLT
CYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPP
QPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIM
FAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ
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| BDBM235879 |
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| n/a |
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| Name | BDBM235879 |
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| Synonyms: | US9364482, 54 |
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| Type | Small organic molecule |
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| Emp. Form. | C36H31F2N5O6S |
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| Mol. Mass. | 699.723 |
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| SMILES | CNC(=O)c1c(oc2cc(N(C)S(C)(=O)=O)c(cc12)-c1ccc2nc(CNC(C)=O)n(Cc3ccc(F)cc3)c(=O)c2c1)-c1ccc(F)cc1 |
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| Structure | 
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