| Reaction Details |
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 | Report a problem with these data |
| Target | Phosphatidylcholine:ceramide cholinephosphotransferase 2 |
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| Ligand | BDBM50545129 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1994372 (CHEMBL4628267) |
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| IC50 | 2.2±n/a nM |
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| Citation |  Yukawa, T; Nakahata, T; Okamoto, R; Ishichi, Y; Miyamoto, Y; Nishimura, S; Oikawa, T; Kubo, K; Adachi, R; Satomi, Y; Nakakariya, M; Amano, N; Kamaura, M; Matsunaga, N Discovery of 1,8-naphthyridin-2-one derivative as a potent and selective sphingomyelin synthase 2 inhibitor. Bioorg Med Chem28:0 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Phosphatidylcholine:ceramide cholinephosphotransferase 2 |
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| Name: | Phosphatidylcholine:ceramide cholinephosphotransferase 2 |
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| Synonyms: | 2.7.8.27 | Phosphatidylcholine:ceramide cholinephosphotransferase 2 | SMS2_MOUSE | Sgms2 | Sphingomyelin synthase 2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 42263.75 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_119194 |
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| Residue: | 365 |
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| Sequence: | MDIIETAKLEGHLESQTNDSTNTYTSPTEAVEEEGKNGKGKPKTLSNGLRKGAKKYPDYI
QISMPNDSKNKFPLEWWKTGIAFVYALFNLILTTVMITVVHERVPPKELSPPLPDKFFDY
FDRVKWAFSVSEINGMVLVGLWITQWLFLRYKSIVGRRFFFIMGTLYLYRCITMYVTTLP
VPGMHFQCAPKLNGDSQAKIQRILRLISGGGLSITGSHILCGDFLFSGHTVVLTLTYLFI
KEYSPRHFWWYHLVCWLLSAAGIICILVAHEHYTVDVIIAYYITTRLFWWYHSMANEKNL
KVSSQTNFLSRAWWFPIFYFFEKNVQGSIPCCFSWPLSWPPGCFKSSCRKYSRVQKIGED
NEKST
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| BDBM50545129 |
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| n/a |
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| Name | BDBM50545129 |
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| Synonyms: | CHEMBL4645607 |
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| Type | Small organic molecule |
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| Emp. Form. | C33H39F3N4O6 |
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| Mol. Mass. | 644.6812 |
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| SMILES | COc1cc(CN(C)C(=O)c2c(OCCCC3CCN(CC3)C(=O)OC3(C)CC3)c3cccnc3n(C)c2=O)cc(c1)C(F)(F)F |
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| Structure | 
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