| Reaction Details |
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 | Report a problem with these data |
| Target | Phosphatidylcholine:ceramide cholinephosphotransferase 1 |
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| Ligand | BDBM50545125 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1994373 (CHEMBL4628268) |
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| IC50 | >100000±n/a nM |
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| Citation |  Yukawa, T; Nakahata, T; Okamoto, R; Ishichi, Y; Miyamoto, Y; Nishimura, S; Oikawa, T; Kubo, K; Adachi, R; Satomi, Y; Nakakariya, M; Amano, N; Kamaura, M; Matsunaga, N Discovery of 1,8-naphthyridin-2-one derivative as a potent and selective sphingomyelin synthase 2 inhibitor. Bioorg Med Chem28:0 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Phosphatidylcholine:ceramide cholinephosphotransferase 1 |
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| Name: | Phosphatidylcholine:ceramide cholinephosphotransferase 1 |
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| Synonyms: | MOB | Medulla oblongata-derived protein | Protein Mob | SGMS1 | SMS1 | SMS1_HUMAN | Sphingomyelin synthase 1 | TMEM23 | Transmembrane protein 23 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 48630.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_109868 |
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| Residue: | 413 |
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| Sequence: | MKEVVYWSPKKVADWLLENAMPEYCEPLEHFTGQDLINLTQEDFKKPPLCRVSSDNGQRL
LDMIETLKMEHHLEAHKNGHANGHLNIGVDIPTPDGSFSIKIKPNGMPNGYRKEMIKIPM
PELERSQYPMEWGKTFLAFLYALSCFVLTTVMISVVHERVPPKEVQPPLPDTFFDHFNRV
QWAFSICEINGMILVGLWLIQWLLLKYKSIISRRFFCIVGTLYLYRCITMYVTTLPVPGM
HFNCSPKLFGDWEAQLRRIMKLIAGGGLSITGSHNMCGDYLYSGHTVMLTLTYLFIKEYS
PRRLWWYHWICWLLSVVGIFCILLAHDHYTVDVVVAYYITTRLFWWYHTMANQQVLKEAS
QMNLLARVWWYRPFQYFEKNVQGIVPRSYHWPFPWPVVHLSRQVKYSRLVNDT
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| BDBM50545125 |
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| n/a |
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| Name | BDBM50545125 |
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| Synonyms: | CHEMBL4635147 |
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| Type | Small organic molecule |
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| Emp. Form. | C33H44N4O7 |
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| Mol. Mass. | 608.7251 |
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| SMILES | COc1cc(CN(C)C(=O)c2c(OCCCC3CCN(CC3)C(=O)OC(C)(C)C)c3cnccc3n(C)c2=O)cc(OC)c1 |
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| Structure | 
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