| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Adenosine kinase |
|---|
| Ligand | BDBM50102927 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_30641 |
|---|
| IC50 | 1.8±n/a nM |
|---|
| Citation |  Zheng, GZ; Lee, C; Pratt, JK; Perner, RJ; Jiang, MQ; Gomtsyan, A; Matulenko, MA; Mao, Y; Koenig, JR; Kim, KH; Muchmore, S; Yu, H; Kohlhaas, K; Alexander, KM; McGaraughty, S; Chu, KL; Wismer, CT; Mikusa, J; Jarvis, MF; Marsh, K; Kowaluk, EA; Bhagwat, SS; Stewart, AO Pyridopyrimidine analogues as novel adenosine kinase inhibitors. Bioorg Med Chem Lett11:2071-4 (2001) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Adenosine kinase |
|---|
| Name: | Adenosine kinase |
|---|
| Synonyms: | ADK | ADK_HUMAN |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 40545.97 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1467841 |
|---|
| Residue: | 362 |
|---|
| Sequence: | MAAAEEEPKPKKLKVEAPQALRENILFGMGNPLLDISAVVDKDFLDKYSLKPNDQILAED
KHKELFDELVKKFKVEYHAGGSTQNSIKVAQWMIQQPHKAATFFGCIGIDKFGEILKRKA
AEAHVDAHYYEQNEQPTGTCAACITGDNRSLIANLAAANCYKKEKHLDLEKNWMLVEKAR
VCYIAGFFLTVSPESVLKVAHHASENNRIFTLNLSAPFISQFYKESLMKVMPYVDILFGN
ETEAATFAREQGFETKDIKEIAKKTQALPKMNSKRQRIVIFTQGRDDTIMATESEVTAFA
VLDQDQKEIIDTNGAGDAFVGGFLSQLVSDKPLTECIRAGHYAASIIIRRTGCTFPEKPD
FH
|
|
|
|---|
| BDBM50102927 |
|---|
| n/a |
|---|
| Name | BDBM50102927 |
|---|
| Synonyms: | 5'-[4-Amino-5-(3-bromo-phenyl)-pyrido[2,3-d]pyrimidin-7-yl]-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-4-ol | CHEMBL62974 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H21BrN6O |
|---|
| Mol. Mass. | 477.356 |
|---|
| SMILES | Nc1ncnc2nc(cc(-c3cccc(Br)c3)c12)-c1ccc(nc1)N1CCC(O)CC1 |
|---|
| Structure | 
|
|---|
Search and Browse
