| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cyclin-dependent kinase 6/G1/S-specific cyclin-D3 |
|---|
| Ligand | BDBM50545382 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1994930 (CHEMBL4628825) |
|---|
| IC50 | 7.9±n/a nM |
|---|
| Citation |  Anderson, NA; Cryan, J; Ahmed, A; Dai, H; McGonagle, GA; Rozier, C; Benowitz, AB Selective CDK6 degradation mediated by cereblon, VHL, and novel IAP-recruiting PROTACs. Bioorg Med Chem Lett30:0 (2020) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cyclin-dependent kinase 6/G1/S-specific cyclin-D3 |
|---|
| Name: | Cyclin-dependent kinase 6/G1/S-specific cyclin-D3 |
|---|
| Synonyms: | CDK6/CycD3 | CDK6/D3 | CDK6/G1/S-specific cyclin D3 | CDK6/cyclin D3 | Cyclin-dependent kinase 6 | Cyclin-dependent kinase 6/G1/S-specific cyclin D3 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | n/a |
|---|
| Description: | n/a |
|---|
| Components: | This complex has 2 components. |
|---|
| Component 1 |
| Name: | Cyclin-dependent kinase 6 |
|---|
| Synonyms: | CDK6 | CDK6_HUMAN | CDKN6 | Cell division protein kinase 6 | Cyclin-dependent kinase 6 (CDK 6) | Serine/threonine-protein kinase PLSTIRE |
|---|
| Type: | Enzyme Subunit |
|---|
| Mol. Mass.: | 36937.42 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q00534 |
|---|
| Residue: | 326 |
|---|
| Sequence: | MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIR
EVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTE
TIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVV
VTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGE
EDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF
QDLERCKENLDSHLPPSQNTSELNTA
|
|
|
|---|
| Component 2 |
| Name: | G1/S-specific cyclin-D3 |
|---|
| Synonyms: | CCND3 | CCND3_HUMAN |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 32521.90 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P30281 |
|---|
| Residue: | 292 |
|---|
| Sequence: | MELLCCEGTRHAPRAGPDPRLLGDQRVLQSLLRLEERYVPRASYFQCVQREIKPHMRKML
AYWMLEVCEEQRCEEEVFPLAMNYLDRYLSCVPTRKAQLQLLGAVCMLLASKLRETTPLT
IEKLCIYTDHAVSPRQLRDWEVLVLGKLKWDLAAVIAHDFLAFILHRLSLPRDRQALVKK
HAQTFLALCATDYTFAMYPPSMIATGSIGAAVQGLGACSMSGDELTELLAGITGTEVDCL
RACQEQIEAALRESLREASQTSSSPAPKAPRGSSSQGPSQTSTPTDVTAIHL
|
|
|
|---|
| BDBM50545382 |
|---|
| n/a |
|---|
| Name | BDBM50545382 |
|---|
| Synonyms: | CHEMBL4646450 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C43H49N11O7 |
|---|
| Mol. Mass. | 831.9187 |
|---|
| SMILES | CC(=O)c1c(C)c2cnc(Nc3ccc(cn3)N3CCN(CCCCNC(=O)CNc4cccc5C(=O)N(C6CCC(=O)NC6=O)C(=O)c45)CC3)nc2n(C2CCCC2)c1=O |
|---|
| Structure | 
|
|---|
Search and Browse
