Reaction Details |
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Target | Stromelysin-1 |
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Ligand | BDBM50063920 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_104901 (CHEMBL713437) |
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Ki | 310±n/a nM |
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Citation | Musso, DL; Andersen, MW; Andrews, RC; Austin, R; Beaudet, EJ; Becherer, JD; Bubacz, DG; Bickett, DM; Chan, JH; Conway, JG; Cowan, DJ; Gaul, MD; Glennon, KC; Hedeen, KM; Lambert, MH; Leesnitzer, MA; McDougald, DL; Mitchell, JL; Moss, ML; Rabinowitz, MH; Rizzolio, MC; Schaller, LT; Stanford, JB; Tippin, T; Warner, JR; Whitesell, LG; Wiethe, RW N-hydroxyformamide peptidomimetics as TACE/matrix metalloprotease inhibitors: oral activity via P1' isobutyl substitution. Bioorg Med Chem Lett11:2147-51 (2001) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Stromelysin-1 |
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Name: | Stromelysin-1 |
Synonyms: | MMP-3 | MMP3 | MMP3_HUMAN | Matrix metalloproteinase (2 and 3) | Matrix metalloproteinase 3 | Matrix metalloproteinase-3 | Matrix metalloproteinase-3 (MMP-3) | Matrix metalloproteinase-3 (MMP3) | SL-1 | STMY1 | Stromelysin 1 | Transin-1 |
Type: | Enzyme |
Mol. Mass.: | 53973.13 |
Organism: | Homo sapiens (Human) |
Description: | P08254 |
Residue: | 477 |
Sequence: | MKSLPILLLLCVAVCSAYPLDGAARGEDTSMNLVQKYLENYYDLKKDVKQFVRRKDSGPV
VKKIREMQKFLGLEVTGKLDSDTLEVMRKPRCGVPDVGHFRTFPGIPKWRKTHLTYRIVN
YTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNV
LAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLY
HSLTDLTRFRLSQDDINGIQSLYGPPPDSPETPLVPTEPVPPEPGTPANCDPALSFDAVS
TLRGEILIFKDRHFWRKSLRKLEPELHLISSFWPSLPSGVDAAYEVTSKDLVFIFKGNQF
WAIRGNEVRAGYPRGIHTLGFPPTVRKIDAAISDKEKNKTYFFVEDKYWRFDEKRNSMEP
GFPKQIAEDFPGIDSKIDAVFEEFGFFYFFTGSSQLEFDPNAKKVTHTLKSNSWLNC
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BDBM50063920 |
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n/a |
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Name | BDBM50063920 |
Synonyms: | (R)-N*1*-((S)-2,2-Dimethyl-1-methylcarbamoyl-propyl)-N*4*-hydroxy-2-isobutyl-succinamide | (R)-N1-((S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-N4-hydroxy-2-isobutylsuccinamide | CHEMBL16520 | Ro-31-9790 |
Type | Small organic molecule |
Emp. Form. | C15H29N3O4 |
Mol. Mass. | 315.4085 |
SMILES | CNC(=O)[C@@H](NC(=O)[C@H](CC(C)C)CC(=O)NO)C(C)(C)C |
Structure |
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