| Reaction Details |
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 | Report a problem with these data |
| Target | C-C chemokine receptor type 2 |
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| Ligand | BDBM50103141 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_41908 (CHEMBL655699) |
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| Ki | 251±n/a nM |
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| Citation |  Witherington, J; Bordas, V; Cooper, DG; Forbes, IT; Gribble, AD; Ife, RJ; Berkhout, T; Gohil, J; Groot, PH Conformationally restricted indolopiperidine derivatives as potent CCR2B receptor antagonists. Bioorg Med Chem Lett11:2177-80 (2001) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| C-C chemokine receptor type 2 |
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| Name: | C-C chemokine receptor type 2 |
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| Synonyms: | C-C chemokine receptor type 2 (CCR2) | CCR2 | CCR2_HUMAN | CMKBR2 | Chemoattractant Cytokine Receptor 2 (CCR2) | Chemokine Receptor Type 2b (CCR2b) | Monocyte chemotactic protein-1 (MCP-1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 41932.32 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P41597 |
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| Residue: | 374 |
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| Sequence: | MLSTSRSRFIRNTNESGEEVTTFFDYDYGAPCHKFDVKQIGAQLLPPLYSLVFIFGFVGN
MLVVLILINCKKLKCLTDIYLLNLAISDLLFLITLPLWAHSAANEWVFGNAMCKLFTGLY
HIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWLVAVFASVPGIIFTK
CQKEDSVYVCGPYFPRGWNNFHTIMRNILGLVLPLLIMVICYSGILKTLLRCRNEKKRHR
AVRVIFTIMIVYFLFWTPYNIVILLNTFQEFFGLSNCESTSQLDQATQVTETLGMTHCCI
NPIIYAFVGEKFRSLFHIALGCRIAPLQKPVCGGPGVRPGKNVKVTTQGLLDGRGKGKSI
GRAPEASLQDKEGA
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| BDBM50103141 |
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| n/a |
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| Name | BDBM50103141 |
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| Synonyms: | (E)-3-(3,4-Dichloro-phenyl)-N-{5-[(1R,5S)-3-(5-hydroxy-1H-indol-3-yl)-8-aza-bicyclo[3.2.1]oct-8-yl]-pentyl}-acrylamide | CHEMBL305470 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H33Cl2N3O2 |
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| Mol. Mass. | 526.497 |
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| SMILES | Oc1ccc2[nH]cc(C3C[C@@H]4CC[C@H](C3)N4CCCCCNC(=O)\C=C\c3ccc(Cl)c(Cl)c3)c2c1 |THB:16:15:8.14.9:11.12| |
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| Structure | 
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