| Reaction Details |
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 | Report a problem with these data |
| Target | Fibroblast growth factor receptor 3 |
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| Ligand | BDBM50525939 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1995345 (CHEMBL4629240) |
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| IC50 | 3.0±n/a nM |
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| Citation |  Kuriwaki, I; Kameda, M; Hisamichi, H; Kikuchi, S; Iikubo, K; Kawamoto, Y; Moritomo, H; Kondoh, Y; Amano, Y; Tateishi, Y; Echizen, Y; Iwai, Y; Noda, A; Tomiyama, H; Suzuki, T; Hirano, M Structure-based drug design of 1,3,5-triazine and pyrimidine derivatives as novel FGFR3 inhibitors with high selectivity over VEGFR2. Bioorg Med Chem28:0 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Fibroblast growth factor receptor 3 |
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| Name: | Fibroblast growth factor receptor 3 |
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| Synonyms: | CD_antigen: CD333 | FGFR-3 | FGFR3 | FGFR3_HUMAN | Fibroblast growth factor receptor | Fibroblast growth factor receptor 3 (FGFR3) | JTK4 |
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| Type: | Protein |
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| Mol. Mass.: | 87699.57 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P22607 |
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| Residue: | 806 |
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| Sequence: | MGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELS
CPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCH
FSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAG
NPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQT
YTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGP
DGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTCLAGNSIGFSHHSAWLVVLPAE
EELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKISRFPLK
RQVSLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGE
GCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIIN
LLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQ
VARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKW
MAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCT
HDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSS
SSSGDDSVFAHDLLPPAPPSSGGSRT
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| BDBM50525939 |
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| n/a |
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| Name | BDBM50525939 |
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| Synonyms: | Balversa | Erdafitinib | Jnj-42756493 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H30N6O2 |
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| Mol. Mass. | 446.5447 |
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| SMILES | COc1cc(OC)cc(c1)N(CCNC(C)C)c1ccc2ncc(nc2c1)-c1cnn(C)c1 |
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| Structure | 
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