| Reaction Details |
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 | Report a problem with these data |
| Target | Histamine H1 receptor |
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| Ligand | BDBM50073179 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1996091 (CHEMBL4629986) |
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| Kd | 24±n/a nM |
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| Citation |  Lall, MS; Bassyouni, A; Bradow, J; Brown, M; Bundesmann, M; Chen, J; Ciszewski, G; Hagen, AE; Hyek, D; Jenkinson, S; Liu, B; Obach, RS; Pan, S; Reilly, U; Sach, N; Smaltz, DJ; Spracklin, DK; Starr, J; Wagenaar, M; Walker, GS Late-Stage Lead Diversification Coupled with Quantitative Nuclear Magnetic Resonance Spectroscopy to Identify New Structure-Activity Relationship Vectors at Nanomole-Scale Synthesis: Application to Loratadine, a Human Histamine H J Med Chem63:7268-7292 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histamine H1 receptor |
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| Name: | Histamine H1 receptor |
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| Synonyms: | H1R | HH1R | HISTAMINE H1 | HRH1 | HRH1_HUMAN |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 55808.72 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Cell pellets from SK-N-MC cells transfected with human H1 receptor were used in binding assay. |
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| Residue: | 487 |
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| Sequence: | MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHT
VGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFI
LCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKC
ETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLR
PENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKL
YCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSR
TDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFI
MAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFK
RILHIRS
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| BDBM50073179 |
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| n/a |
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| Name | BDBM50073179 |
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| Synonyms: | 8-Chloro-11-piperidin-4-ylidene-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine | CHEMBL1172 | Clarinex | Claritin | Claritin-D | DESLORATADINE | SCH-34117 | US9138431, DESLORATADINE (Clarinex) | US9333199, DESLORATADINE (Clarinex) |
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| Type | Small organic molecule |
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| Emp. Form. | C19H19ClN2 |
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| Mol. Mass. | 310.821 |
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| SMILES | Clc1ccc2c(-[#6]-[#6]-c3cccnc3\[#6]-2=[#6]-2/[#6]-[#6]-[#7]-[#6]-[#6]-2)c1 |
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| Structure | 
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