| Reaction Details |
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 | Report a problem with these data |
| Target | Tumor necrosis factor |
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| Ligand | BDBM50545753 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1996516 (CHEMBL4630411) |
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| Kd | 4260±n/a nM |
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| Citation |  Sun, W; Wu, Y; Zheng, M; Yang, Y; Liu, Y; Wu, C; Zhou, Y; Zhang, Y; Chen, L; Li, H Discovery of an Orally Active Small-Molecule Tumor Necrosis Factor-? Inhibitor. J Med Chem63:8146-8156 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tumor necrosis factor |
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| Name: | Tumor necrosis factor |
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| Synonyms: | Cachectin | TNF | TNF-a | TNF-alpha | TNFA | TNFA_HUMAN | TNFSF2 | Tumor necrosis factor (TNF-alpha) | Tumor necrosis factor (TNFa) | Tumor necrosis factor alpha (TNFα) | Tumor necrosis factor ligand superfamily member 2 | Tumor necrosis factor, membrane form | Tumor necrosis factor, soluble form | tumor necrosis factor alpha |
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| Type: | Enzyme |
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| Mol. Mass.: | 25645.11 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P01375 |
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| Residue: | 233 |
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| Sequence: | MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQR
EEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELR
DNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRE
TPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL
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| BDBM50545753 |
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| n/a |
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| Name | BDBM50545753 |
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| Synonyms: | CHEMBL4649816 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H16N6O |
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| Mol. Mass. | 308.3378 |
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| SMILES | O=C1C[C@@H](CN1Cc1ccccc1)Nc1ncnc2[nH]cnc12 |r| |
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| Structure | 
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