| Reaction Details |
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 | Report a problem with these data |
| Target | Dual specificity protein kinase CLK1 |
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| Ligand | BDBM50148456 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2012563 (CHEMBL4666141) |
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| IC50 | 133±n/a nM |
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| Citation |  Tazarki, H; Zeinyeh, W; Esvan, YJ; Knapp, S; Chatterjee, D; Schröder, M; Joerger, AC; Khiari, J; Josselin, B; Baratte, B; Bach, S; Ruchaud, S; Anizon, F; Giraud, F; Moreau, P New pyrido[3,4-g]quinazoline derivatives as CLK1 and DYRK1A inhibitors: synthesis, biological evaluation and binding mode analysis. Eur J Med Chem166:304-317 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dual specificity protein kinase CLK1 |
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| Name: | Dual specificity protein kinase CLK1 |
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| Synonyms: | CDC-like kinase 1 | CLK1_MOUSE | Clk | Clk1 | Protein kinase STY | Sty |
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| Type: | PROTEIN |
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| Mol. Mass.: | 57124.52 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_1502245 |
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| Residue: | 483 |
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| Sequence: | MRHSKRTYCPDWDERDWDYGTWRSSSSHKRKKRSHSSAREQKRCRYDHSKTTDSYYLESR
SINEKAYHSRRYVDEYRNDYMGYEPGHPYGEPGSRYQMHSSKSSGRSGRSSYKSKHRSRH
HTSQHHSHGKSHRRKRSRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDH
KVGGRRVAVKIVKNVDRYCEAAQSEIQVLEHLNTTDPHSTFRCVQMLEWFEHRGHICIVF
ELLGLSTYDFIKENSFLPFRMDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVKSDY
TEAYNPKMKRDERTIVNPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCD
VWSIGCILIEYYLGFTVFPTHDSREHLAMMERILGPLPKHMIQKTRKRRYFHHDRLDWDE
HSSAGRYVSRRCKPLKEFMLSQDAEHELLFDLIGKMLEYDPAKRITLKEALKHPFFYPLK
KHT
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| BDBM50148456 |
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| n/a |
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| Name | BDBM50148456 |
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| Synonyms: | CHEMBL4785650 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H23N7O2 |
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| Mol. Mass. | 381.4316 |
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| SMILES | CN1CCN(CCCNc2ncc3cc4cnccc4c([N+]([O-])=O)c3n2)CC1 |
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| Structure | 
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