Reaction Details |
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Target | Potassium channel subfamily K member 10 |
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Ligand | BDBM50546003 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2013745 (CHEMBL4667323) |
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EC50 | 7700±n/a nM |
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Citation | Iwaki, Y; Yashiro, K; Kokubo, M; Mori, T; Wieting, JM; McGowan, KM; Bridges, TM; Engers, DW; Denton, JS; Kurata, H; Lindsley, CW Towards a TREK-1/2 (TWIK-Related K+ Channel 1 and 2) dual activator tool compound: Multi-dimensional optimization of BL-1249. Bioorg Med Chem Lett29:1601-1604 (2019) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Potassium channel subfamily K member 10 |
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Name: | Potassium channel subfamily K member 10 |
Synonyms: | KCNK10 | KCNKA_HUMAN | Outward rectifying potassium channel protein TREK-2 | Potassium channel subfamily K member 10 | TREK-2 K(+) channel subunit | TREK2 |
Type: | PROTEIN |
Mol. Mass.: | 59774.98 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_105637 |
Residue: | 538 |
Sequence: | MFFLYTDFFLSLVAVPAAAPVCQPKSATNGQPPAPAPTPTPRLSISSRATVVARMEGTSQ
GGLQTVMKWKTVVAIFVVVVVYLVTGGLVFRALEQPFESSQKNTIALEKAEFLRDHVCVS
PQELETLIQHALDADNAGVSPIGNSSNNSSHWDLGSAFFFAGTVITTIGYGNIAPSTEGG
KIFCILYAIFGIPLFGFLLAGIGDQLGTIFGKSIARVEKVFRKKQVSQTKIRVISTILFI
LAGCIVFVTIPAVIFKYIEGWTALESIYFVVVTLTTVGFGDFVAGGNAGINYREWYKPLV
WFWILVGLAYFAAVLSMIGDWLRVLSKKTKEEVGEIKAHAAEWKANVTAEFRETRRRLSV
EIHDKLQRAATIRSMERRRLGLDQRAHSLDMLSPEKRSVFAALDTGRFKASSQESINNRP
NNLRLKGPEQLNKHGQGASEDNIINKFGSTSRLTKRKNKDLKKTLPEDVQKIYKTFRNYS
LDEEKKEEETEKMCNSDNSSTAMLTDCIQQHAELENGMIPTDTKDREPENNSLLEDRN
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BDBM50546003 |
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n/a |
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Name | BDBM50546003 |
Synonyms: | CHEMBL4759642 |
Type | Small organic molecule |
Emp. Form. | C15H9BrF3NO3S |
Mol. Mass. | 420.201 |
SMILES | OC(=O)c1cc(Br)ccc1NC(=O)c1ccc(SC(F)(F)F)cc1 |
Structure |
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